7-Methoxy-2-naphthol

Base Information

• Chemical Name: 7-Methoxy-2-naphthol
• CAS No.: 5060-82-2
• Molecular Formula: C11H10O2
• Molecular Weight: 174.199
• Hs Code.: 29071990
• European Community (EC) Number: 629-282-9
• DSSTox Substance ID: DTXSID80357408
• Nikkaji Number: J770.043A
• ChEMBL ID: CHEMBL4226925
• Mol file: 5060-82-2.mol

Synonyms:7-Methoxy-2-naphthol;7-methoxynaphthalen-2-ol;5060-82-2;MFCD00075494;2-Naphthalenol, 7-methoxy-;2-Methoxy-7-naphthol;7-methoxy-beta-naphthol;7-methoxy-naphthalen-2-ol;SCHEMBL216905;7-(methyloxy)-2-naphthalenol;2-hydroxy-7-methoxynaphthalene;7-Methoxy-2-naphthol, 98%;CHEMBL4226925;DTXSID80357408;UNFNRIIETORURP-UHFFFAOYSA-N;GEO-01697;AKOS001434501;CS-W017503;DS-18565;SY063965;AM20040581;FT-0635526;EN300-16482;A828200;W-200398

Chemical Property of 7-Methoxy-2-naphthol

Chemical Property:

• Vapor Pressure: 5.65E-05mmHg at 25°C
• Melting Point: 116-119 °C(lit.)
• Refractive Index: 1.64
• Boiling Point: 336.7 °C at 760 mmHg
• PKA: 9.45±0.40(Predicted)
• Flash Point: 211.9 °C
• PSA: 29.46000
• Density: 1.193 g/cm³
• LogP: 2.55400
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 174.068079557
• Heavy Atom Count: 13
• Complexity: 170

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Methoxy-2-naphthol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=CC(=C2)O)C=C1
• Uses: 7-Methoxy-2-naphthol may be used in the synthesis of new 1H-benzo[f]chromene derivatives. It may be used in the synthesis of 7-methoxy-2-naphthyl (MN)-derived xylosides in which the methoxy group served as a marker for NMR characterization and UV detection.

Technology Process of 7-Methoxy-2-naphthol

There total 2 articles about 7-Methoxy-2-naphthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

methanol (67-56-1) + 2,7-Dihydroxynaphthalene (582-17-2) → 2,7-Dimethoxynaphthalene (3469-26-9) + 7-methoxy-2-naphthol (5060-82-2)

Guidance literature:

With hydrogenchloride; for 72h; Ambient temperature;

DOI:10.1071/CH9930731

Reference yield:

2,7-Dihydroxynaphthalene (582-17-2) + dimethyl sulfate (77-78-1) → 2,7-Dimethoxynaphthalene (3469-26-9) + 7-methoxy-2-naphthol (5060-82-2)

Guidance literature:

With sodium hydroxide;

Reference yield: 100.0%

3-chloro-4-fluoronitrobenzene (350-30-1) + 7-methoxy-2-naphthol (5060-82-2) → 3-chloro-4-(7-methoxynaphth-2-oxy)nitrobenzene

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 17h;

DOI:10.1016/j.bmcl.2020.127408

upstream raw materials:

2,7-Dihydroxynaphthalene

dimethyl sulfate

methanol

Downstream raw materials:

2-hydroxy-7-methoxynaphthalene-1-azobenzene

2-amino-7-methoxynaphthalene

1-(2-amino-phenyl)-7-methoxy-[2]naphthylamine

dimethyl 2,2'-dihydroxy-1,1'-binaphthalene-3,3'-dicarboxylate

Refernces

• 1、 Guy, Alain,Lemaire, Marc,Guette, Jean-Paul. "HALOGENATION REGIOSELECTIVE EN SERIE AROMATIQUE-II CHLORATION DES NAPHTOLS ET LEURS ETHERS A L'AIDE DE REACTIFS METTANT EN JEU DES INTERACTIONS DU TYPE DONNEUR-ACCEPTEUR". . p. 2347 - 2354. Retrieved 2007/10/02.