4-(2-Methoxyethoxy)phenol

Base Information

• Chemical Name: 4-(2-Methoxyethoxy)phenol
• CAS No.: 51980-60-0
• Molecular Formula: C9H12O3
• Molecular Weight: 168.192
• Hs Code.: 2909500000
• European Community (EC) Number: 826-063-1
• DSSTox Substance ID: DTXSID00536435
• Wikidata: Q82411090
• Mol file: 51980-60-0.mol

Synonyms:4-(2-Methoxyethoxy)phenol;51980-60-0;4-(2-Methoxy-ethoxy)-phenol;MFCD04114941;4-(2-Methoxyethoxyl)phenol;SCHEMBL77538;F2147-0872;DTXSID00536435;NIGIGWPNXVNZRK-UHFFFAOYSA-N;AKOS009316994;AB19320;AS-30834;SY042947;4-(2-methoxy-ethoxy)-phenol, AldrichCPR;CS-0150171;EN300-199522;A828870;Z381414750;3 inverted exclamation mark -Trifluoromethylbiphenyl-3-carbaldehyde

Chemical Property of 4-(2-Methoxyethoxy)phenol

Chemical Property:

• PSA: 38.69000
• LogP: 1.41740
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 168.078644241
• Heavy Atom Count: 12
• Complexity: 108

Purity/Quality:

98%Min ^*data from raw suppliers

4-(2-Methoxy-ethoxy)-phenol 97% ^*data from reagent suppliers

Safty Information:

• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCOC1=CC=C(C=C1)O
• Uses: 4-(2-Methoxyethoxy)phenol is a reactant used in the preparation of (2-?fluoro-?4-?methanesulfonylphenyl)?-?{6-?[4-?(3-?isopropyl-?[1,?2,?4]?oxadiazol-?5-?yl)?-?piperidin-?1-?yl]?-?5-?nitro-?pyrimidin-?4-?yl}?-?amine, an oral agonist of orphan G-protein coupled receptor 119.

Technology Process of 4-(2-Methoxyethoxy)phenol

There total 5 articles about 4-(2-Methoxyethoxy)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.6%

(4-hydroxyphenyl)methanol (623-05-2) + 2-Bromoethyl methyl ether (6482-24-2) → (4-(2-methoxyethoxy)phenol) (51980-60-0)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In acetone; for 72h; Reflux;

Reference yield: 51.0%

2-methoxy-ethanol (109-86-4,95507-80-5) + hydroquinone (123-31-9,8027-02-9) → (4-(2-methoxyethoxy)phenol) (51980-60-0)

Guidance literature:

phosphomolybdic acid; for 6h; Heating;

DOI:10.1016/S0960-894X(99)00701-5

Reference yield: 34.0%

2-methoxy-ethyl p-toluenesulfonyloxy ester (17178-10-8,58320-73-3) + hydroquinone (123-31-9,8027-02-9) → (4-(2-methoxyethoxy)phenol) (51980-60-0)

Guidance literature:

With potassium carbonate; In acetonitrile; Heating;

DOI:10.1002/1521-3765(20010618)7:12<2687::AID-CHEM26870>3.0.CO;2-A

upstream raw materials:

2-methoxy-ethanol

hydroquinone

2-methoxy-ethyl p-toluenesulfonyloxy ester

(4-hydroxyphenyl)methanol

Downstream raw materials:

C₉H₁₁Cl₂O₄P

2-(2-{2-[4-(2-Methoxyethoxy)phenoxy]ethoxy}ethoxy)ethanol

1-(2-bromo-5-chlorobenzyloxy)-4-(2-methoxyethoxy)benzene

C₁₃H₁₉ClNO₆P