2-Methoxyethyl 4-methylbenzenesulfonate

Base Information

• Chemical Name: 2-Methoxyethyl 4-methylbenzenesulfonate
• CAS No.: 17178-10-8
• Deprecated CAS: 187250-61-9,188266-38-8
• Molecular Formula: C10H14 O4 S
• Molecular Weight: 230.285
• Hs Code.: 2909499000
• European Community (EC) Number: 688-184-4
• DSSTox Substance ID: DTXSID00884963
• Nikkaji Number: J141.675H
• Wikidata: Q82863601
• Mol file: 17178-10-8.mol

Synonyms:2-methoxyethyl 4-methylbenzenesulfonate;17178-10-8;2-Methoxyethyl p-Toluenesulfonate;p-Toluenesulfonic Acid 2-Methoxyethyl Ester;58320-73-3;2-methoxyethyl tosylate;m-PEG11-OTs;Ethanol, 2-methoxy-, 4-methylbenzenesulfonate;C10H14O4S;4-Methylbenzenesulfonic acid 2-methoxyethyl ester;Ethanol, 2-methoxy-, 1-(4-methylbenzenesulfonate);MFCD00025910;mPEG-Tosylate;mPEG-Tos;2-methoxyethyltosylate;SCHEMBL85631;2-methoxyethyl-p-toluenesulfonate;DTXSID00884963;2-methoxyethyl p-toluenesulphonate;AC8517;ethylene glycol methyl ether tosylate;beta-methyloxyethyl p-toluenesulfonate;AKOS005111040;CS-W023070;DS-15286;p-toluenesulfonic acid-2-methoxyethylester;SY047023;2-methoxyethyl 4-methylbenzene-1-sulfonate;FT-0725657;p-toluene sulfonic acid 2-methoxyethyl ester;T1303;toluene-4-sulfonic acid 2-methoxy-ethyl ester;EN300-7203603;A811352;188266-38-8

Chemical Property of 2-Methoxyethyl 4-methylbenzenesulfonate

Chemical Property:

• Vapor Pressure: 0.000135mmHg at 25°C
• Melting Point: 10 °C
• Refractive Index: 1.507
• Boiling Point: 141 °C / 0.2mmHg
• Flash Point: 161.8°C
• PSA: 60.98000
• Density: 1.21
• LogP: 2.42750
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 230.06128010
• Heavy Atom Count: 15
• Complexity: 260

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methoxyethyl p-Toluenesulfonate >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)OCCOC

Technology Process of 2-Methoxyethyl 4-methylbenzenesulfonate

There total 9 articles about 2-Methoxyethyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methoxy-ethanol (109-86-4,95507-80-5) + p-toluenesulfonyl chloride (98-59-9) → 2-methoxy-ethyl p-toluenesulfonyloxy ester (17178-10-8,58320-73-3)

Guidance literature:

In pyridine; at 0 ℃; for 3.5h;

DOI:10.1039/b617347k

Reference yield: 100.0%

2-(2-methoxyethoxy)ethyl alcohol (111-77-3,95507-80-5) + p-toluenesulfonyl chloride (98-59-9) → 2-methoxy-ethyl p-toluenesulfonyloxy ester (17178-10-8,58320-73-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.8b00289

Reference yield: 69.0%

2-methoxy-ethanol (109-86-4,95507-80-5) + toluene-4-sulfonic acid (104-15-4) → 2-methoxy-ethyl p-toluenesulfonyloxy ester (17178-10-8,58320-73-3)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

upstream raw materials:

2-methoxy-ethanol

p-toluenesulfonyl chloride

oxirane

methyl p-toluene sulfonate

Downstream raw materials:

2-methoxyethyl phenyl ether

<4-Acetamino-2-butyryl-phenyl>-<2-aethoxy-aethyl>-aether

5-(N,N-dibenzylglycyl)-2-(2-methoxyethoxy)benzamide

(2-Methoxy-ethyl)-(2-methoxy-5-trifluoromethyl-phenyl)-amine

Refernces

• 1、 Naemura, Koichiro,Fukunaga, Rinko,Komatsu, Masanori,Yamanaka, Masatoshi,Chikamatsu, Hiroaki. "Synthesis and Enantiomer Recognition of Dipodands and Crown Ethers Containing the 2,3:6,7-Dibenzobicyclonona-2,6-diene Residue as the Chiral Subunit". . p. 83 - 88. Retrieved 1989.
• 2、 Rajca, Andrzej,Mukherjee, Sumit,Pink, Maren,Rajca, Suchada. "Exchange coupling mediated through-bonds and through-space in conformationally constrained polyradical scaffolds: Calix[4]arene nitroxide tetraradicals and diradical". . p. 13497 - 13507. Retrieved 2006.
• 3、 Liu, Jinbing,Wu, Fengyan,Chen, Changhong. "Design and synthesis of aloe-emodin derivatives as potent anti-tyrosinase, antibacterial and anti-inflammatory agents". . p. 5142 - 5146. Retrieved 2015.
• 4、 Herkert, Lorena,Selter, Philipp,Daniliuc, Constantin G.,B?umer, Nils,Palakkal, Jasnamol P.,Fernández, Gustavo,Hansen, Michael Ryan. "Tuning the Molecular Packing of Self-Assembled Amphiphilic PtII Complexes by Varying the Hydrophilic Side-Chain Length". supporting information. p. 4617 - 4626. Retrieved 2021/02/09.