3-(2-FLUOROPHENYL)PROPIONYL CHLORIDE 98

Base Information

• Chemical Name: 3-(2-FLUOROPHENYL)PROPIONYL CHLORIDE 98
• CAS No.: 52163-89-0
• Molecular Formula: C9H8ClFO
• Molecular Weight: 186.613
• Hs Code.: 2916399090
• Mol file: 52163-89-0.mol

Synonyms:3-(2-FLUOROPHENYL)PROPIONYL CHLORIDE 98;3-(2-Fluorophenyl)propionyl chloride 98%;3-(2-Fluorophenyl)propionyl chloride, HPLC 98%

Chemical Property of 3-(2-FLUOROPHENYL)PROPIONYL CHLORIDE 98

Chemical Property:

• Refractive Index: 1.51
• Boiling Point: 245.3°Cat760mmHg
• Flash Point: 102.2°C
• PSA: 17.07000
• Density: 1.231g/cm³
• LogP: 2.52370

Purity/Quality:

98%Min ^*data from raw suppliers

3-(2-Fluorophenyl)propionylchloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-FLUOROPHENYL)PROPIONYL CHLORIDE 98

There total 6 articles about 3-(2-FLUOROPHENYL)PROPIONYL CHLORIDE 98 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-(2-fluorophenyl)propionic acid (1643-26-1) → 3-(2-fluorophenyl)propanoyl chloride (52163-89-0)

Guidance literature:

With thionyl chloride; for 1h; Heating;

Reference yield:

oxalyl dichloride (79-37-8) + 3-(2-fluorophenyl)propionic acid (1643-26-1) → 3-(2-fluorophenyl)propanoyl chloride (52163-89-0)

Guidance literature:

In N-methyl-acetamide;

Reference yield:

o-fluorobenzyl bromide (446-48-0) → 3-(2-fluorophenyl)propanoyl chloride (52163-89-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / sodium ethoxide / ethanol / Heating

2: 78 percent / aq. potassium hydroxide

3: 81 percent / thionyl chloride / 1 h / Heating

With potassium hydroxide; thionyl chloride; sodium ethanolate; In ethanol;

upstream raw materials:

3-(2-fluorophenyl)propionic acid

o-fluorobenzyl bromide

diethyl 2-(2-fluorophenyl)ethane-1,1-dicarboxylate

2-fluorocinnamic acid

Downstream raw materials:

4-fluoro-1-indanone

3-[2-(fluoro)phenyl]propionamide

3-(2-fluorophenyl)-N-(t-butyl)propanamide

4-fluoro-indan-1-ol