3-AMINO-6-METHYLPYRIDIN-2-OL

Base Information

• Chemical Name: 3-AMINO-6-METHYLPYRIDIN-2-OL
• CAS No.: 52334-79-9
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.14
• Hs Code.: 2933399090
• European Community (EC) Number: 832-833-8
• DSSTox Substance ID: DTXSID30569014
• Wikidata: Q72490225
• Mol file: 52334-79-9.mol

Synonyms:CHEMPACIFIC 38201;3-AMINO-6-METHYLPYRIDIN-2-OL;3-AMINO-2-HYDROXY-6-METHYL-PYRIDINE

Chemical Property of 3-AMINO-6-METHYLPYRIDIN-2-OL

Chemical Property:

• Vapor Pressure: 5.27E-06mmHg at 25°C
• Refractive Index: 1.626
• Boiling Point: 370.2°C at 760 mmHg
• PKA: 13.97±0.10(Predicted)
• Flash Point: 177.7°C
• PSA: 59.14000
• Density: 1.245g/cm³
• LogP: 1.25900
• Storage Temp.: 2-8°C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 124.063662883
• Heavy Atom Count: 9
• Complexity: 203

Purity/Quality:

98%Min ^*data from raw suppliers

3-Amino-6-methylpyridin-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C(=O)N1)N

Technology Process of 3-AMINO-6-METHYLPYRIDIN-2-OL

There total 4 articles about 3-AMINO-6-METHYLPYRIDIN-2-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-methyl-3-nitrohydropyridin-2-one (39745-39-6) → 2-hydroxy-6-methyl-3-aminopyridine (52334-79-9)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; for 12h; under 750.075 - 4500.45 Torr;

DOI:10.1021/acs.jmedchem.8b00368

Reference yield:

4-chloro-2-hydroxy-6-methyl-3-nitropyridine (95835-64-6) → 2-hydroxy-6-methyl-3-aminopyridine (52334-79-9)

Guidance literature:

With sodium acetate; palladium; Hydrogenation;

Reference yield:

6-hydroxy-2-methylpyridine (3279-76-3,91914-07-7) → 2-hydroxy-6-methyl-3-aminopyridine (52334-79-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; water; nitric acid (D:1.4)

2: palladium; methanol. sodium acetate / Hydrogenation

With water; nitric acid; sodium acetate; palladium; acetic acid;

upstream raw materials:

6-methyl-3-nitrohydropyridin-2-one

4-chloro-2-hydroxy-6-methyl-3-nitropyridine

6-hydroxy-2-methylpyridine

2,4-Dihydroxy-6-methyl-3-nitropyridine

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