2-Fluoro-1-naphthol

Base Information

• Chemical Name: 2-Fluoro-1-naphthol
• CAS No.: 56874-95-4
• Molecular Formula: C10H7FO
• Molecular Weight: 162.16
• DSSTox Substance ID: DTXSID40375749
• Nikkaji Number: J701.648D
• Wikidata: Q82164411
• Mol file: 56874-95-4.mol

Synonyms:2-fluoro-1-naphthol;56874-95-4;2-fluoronaphthalen-1-ol;2-fluoro-1-naphthalenol;2-fluoranylnaphthalen-1-ol;2-fluoro-naphthalen-1-ol;SCHEMBL590476;DTXSID40375749;WHWCIQOXYOFFLF-UHFFFAOYSA-N;2-FLUORO-1-HYDROXYNAPHTHALENE;AKOS006230111;MB04146;FT-0640422;EN300-6479931;A831219;Z1198170673

Chemical Property of 2-Fluoro-1-naphthol

Chemical Property:

• Vapor Pressure: 0.00217mmHg at 25°C
• Melting Point: 72-74 °C
• Refractive Index: 1.649
• Boiling Point: 280.8°C at 760 mmHg
• PKA: 6.86±0.50(Predicted)
• Flash Point: 153.9°C
• PSA: 20.23000
• Density: 1.285g/cm³
• LogP: 2.68450
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 162.048093005
• Heavy Atom Count: 12
• Complexity: 160

Purity/Quality:

98%Min ^*data from raw suppliers

2-FLUORO-1-NAPHTHOL 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC(=C2O)F

Technology Process of 2-Fluoro-1-naphthol

There total 13 articles about 2-Fluoro-1-naphthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

[bromo(difluoro)methyl]-trimethyl-silane (115262-01-6) + inden-1-one (83-33-0) → 2-fluoro-1-hydroxynaphthalene (56874-95-4)

Guidance literature:

[bromo(difluoro)methyl]-trimethyl-silane; inden-1-one; With tetrabutylammomium bromide; In toluene; at 110 ℃; for 7h; Sealed tube;

With tetrabutyl ammonium fluoride; In toluene; at 20 ℃; for 2h; Temperature;

DOI:10.1039/c5cc06825h

Reference yield: 85.0%

1-difluoromethoxy-2-fluoronaphthalene (878998-79-9) → 2-fluoro-1-hydroxynaphthalene (56874-95-4)

Guidance literature:

With hydrogen bromide; acetic acid; at 120 ℃; for 14h;

DOI:10.1016/j.jfluchem.2004.11.006

Reference yield: 71.0%

C15H10FNO → 2-fluoro-1-hydroxynaphthalene (56874-95-4)

Guidance literature:

C₁₅H₁₀FNO; With methyl trifluoromethanesulfonate; In toluene; at 100 ℃;

With methanol; sodium; at 90 ℃;

DOI:10.1021/acscatal.5b00306

upstream raw materials:

α-naphthol

1-difluoromethoxy-2-fluoronaphthalene

inden-1-one

N-(tert-butyl)-N-fluoro-4-methylbenzenesulfonamide