racemic-1,3-Diphenylpropane-1,3-diol

Base Information

• Chemical Name: racemic-1,3-Diphenylpropane-1,3-diol
• CAS No.: 5355-61-3
• Molecular Formula: C₁₅H₁₆O₂
• Molecular Weight: 228.291
• Mol file: 5355-61-3.mol

Synonyms:racemic-1,3-Diphenylpropane-1,3-diol

Chemical Property of racemic-1,3-Diphenylpropane-1,3-diol

Chemical Property:

• PSA: 40.46000
• LogP: 2.84370

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of racemic-1,3-Diphenylpropane-1,3-diol

There total 54 articles about racemic-1,3-Diphenylpropane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-hydroxy-1,3-diphenylpropan-1-one (42052-51-7) → 1,3-diphenyl-1,3-propanediol (5355-61-3,5381-86-2,59825-14-8,77291-92-0,108391-15-7,5471-97-6)

Guidance literature:

With samarium diiodide; water; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

DOI:10.1021/ol047835p

Reference yield: 93.0%

1,3-diphenylpropanedione (120-46-7,61346-73-4) → dihydrochalcone (1083-30-3) + 1,3-diphenylpropan-1-ol (14097-24-6) + 1,3-diphenyl-1,3-propanediol (5355-61-3,5381-86-2,59825-14-8,77291-92-0,108391-15-7,5471-97-6)

Guidance literature:

With samarium diiodide; water; In tetrahydrofuran; at 20 ℃; for 0.0666667h;

DOI:10.1248/cpb.53.1017

Reference yield: 90.0%

1,3-diphenyl-propen-3-one (614-47-1) → 1,3-diphenyl-1,3-propanediol (5355-61-3,5381-86-2,59825-14-8,77291-92-0,108391-15-7,5471-97-6)

Guidance literature:

1,3-diphenyl-propen-3-one; With lithium aluminium tetrahydride; oxygen; In tetrahydrofuran; at 0 ℃; for 1.5h;

With water; In tetrahydrofuran;

DOI:10.1016/S0040-4039(99)01270-8

upstream raw materials:

1-bromomercurio-2-hydroxy-2-phenylethane

benzaldehyde

3-hydroxy-1,3-diphenylpropan-1-one

1-phenyl-2-chloroethanol

Downstream raw materials:

1,3-diphenylpropanedione

1,3-diphenyl-1,3-dimethoxy propane

1,3-diphenyl-1-methoxy-3-hydroxy propane

Refernces

• 1、 Merad, Jérémy,Borkar, Prashant,Caijo, Frédéric,Pons, Jean-Marc,Parrain, Jean-Luc,Chuzel, Olivier,Bressy, Cyril. "Double Catalytic Kinetic Resolution (DoCKR) of Acyclic anti-1,3-Diols: The Additive Horeau Amplification". supporting information. p. 16052 - 16056. Retrieved 2017/11/21.
• 2、 Ki?ic, Andrea,Stephan, Michel,Mohar, Barbara. "Ansa-Ruthenium(II) Complexes of R2NSO2DPEN-(CH2)n(η6-Aryl) Conjugate Ligands for Asymmetric Transfer Hydrogenation of Aryl Ketones". supporting information. p. 2540 - 2546. Retrieved 2015/08/18.