42052-51-7Relevant academic research and scientific papers
Novel use of cross-linked poly(N-isopropylacrylamide) gel for organic reactions in aqueous media
Hamamoto, Hiromi,Kudoh, Masahiro,Takahashi, Hideyo,Ikegami, Shiro
, p. 4015 - 4018 (2006)
A poly(N-isopropylacrylamide) (PNIPAAm) gel cross-linked with quaternized aminoalkyls was designed. A novel recyclable system based on the external solvent-responsive oil-absorption/elution transition ability of the PNIPAAm gel matrix was then developed.
Palladium diaqua and hydroxo complexes with polymer-supported BINAP ligands and their use for catalytic enantioselective reactions
Fujii, Akio,Sodeoka, Mikiko
, p. 8011 - 8014 (1999)
We report the preparation of palladium complexes with the polymer-supported BINAP ligands, [Pd(PS-(R)-binap)(H2O)2]2+(BF4-)2 (5) and [{Pd(PS-(R)-binap)(μ-OH)}2]2+(BFs
Selective Cα-O Bond Cleavage of α,β-Epoxy Ketones to Aldols induced by Free Radical Processes
Hasegawa, Eietsu,Ishiyama, Kenyuki,Horaguchi, Takaaki,Shimizu, Takahachi
, p. 550 - 552 (1990)
Several α,β-epoxy ketones were converted to aldols in good yields upon irradiation or heating with azoisobutyronitrile in the presence of tributyltin hydride in benzene; the reactions involve selective Cα-O bond cleavage of the oxiranylmethyl r
Chiral Bipyridine Ligand with Flexible Molecular Recognition Site: Development and Application to Copper-Catalyzed Asymmetric Borylation of α,β-Unsaturated Ketones
Tsutsumi, Ryosuke,Taguchi, Rika,Yamanaka, Masahiro
, (2021/10/20)
A novel chiral bipyridine ligand bearing a flexible side chain with a molecular recognition site enables precise stereocontrol through the cooperative action of metal center and hydrogen bonds. This new chiral ligand was applied to the copper-catalyzed as
Peroxide- And transition metal-free electrochemical synthesis of α,β-epoxy ketones
Zhang, Mengxun,Chen, Tie,Fang, Shisong,Wu, Weihua,Wang, Xin,Wu, Haiqiang,Xiong, Yongai,Song, Jun,Li, Chenyang,He, Zhendan,Lee, Chi-Sing
supporting information, p. 2481 - 2486 (2021/04/02)
A novel electrochemical method for the synthesis of α,β-epoxy ketones is reported. With KI as the redox mediator, methyl ketones reacted with aldehydes under peroxide- and transition metal-free electrolytic conditions and afforded α,β-epoxy ketones in one pot (36 examples, 52-90% yield). This safe and environmental-friendly method has a broad substrate scope and can readily provide a variety of α,β-epoxy ketones in gram-scales for evaluation of their anti-cancer activities.
Cellulosic CuI Nanoparticles as a Heterogeneous, Recyclable Catalyst for the Borylation of α,β-Unsaturated Acceptors in Aqueous Media
Zhou, Lijie,Han, Biao,Zhang, Yaoyao,Li, Bojie,Wang, Liansheng,Wang, Jianying,Wang, Xianbao,Zhu, Lei
, p. 3220 - 3229 (2021/03/06)
Abstract: We have demonstrated that cellulosic CuI nanoparticles could perform as an efficient heterogeneous catalyst for the synthesis of useful organoboron compounds. Desired β-borylation products were all obtained in good to excellent yields under mild
Synthesis method of alpha or beta-substituted aromatic ketone
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Paragraph 0022-0027; 0109-0111, (2021/05/01)
The invention discloses a synthesis method of alpha-or beta-substituted aromatic ketone. The method comprises the following steps: under the condition of inert gas, reacting alpha-oxo-aryl ethanone compounds, B2pin2, PDI-CoCl2 and MBHEt3 in an organic solvent at room temperature, then adding a compound 2, and continuously reacting to obtain a compound 3, wherein in the MBHEt3, M is an alkali metal; the compound 2 is selected from the group consisting of deuterated methanol, Selectfluoro, a TogniII reagent or R2CHO; R2 is an aromatic substituent or alkyl; the organic solvent is an aprotic organic solvent. According to the method, the alpha-oxo aryl ethanone is used as a raw material, a cheap and stable boron reagent and an efficient cobalt catalyst which is cheap and easy to obtain are used, an activating reagent MBHEt3 is added to generate an enol boron ether intermediate, then the enol boron ether intermediate and different electrophilic reagents are synthesized into alpha-or beta-substituted aromatic ketone, the reaction is carried out at normal temperature, and the operation is convenient.
All at once arrangement of both oxygen atoms of dioxygen into aliphatic C(sp3)-C(sp3) bonds for hydroxyketone difunctionalization
Qiao, Xiaofeng,Lin, Yuhan,Li, Jiazhen,Ma, Wanhong,Zhao, Jincai
, p. 770 - 777 (2021/04/09)
Both β- and γ- hydroxyketone structures are important units in biologically active molecules, synthetic drugs and fine chemicals. Although there are some routes available for their manufacture from pre-functionalized groups on one or two matrix molecule(s), the approaches to simply and simultaneously deposit two oxygen atoms from dioxygen into two specific C(sp3) positions of pure saturated hydrocarbons have rarely succeeded because they are involved in the targeted activation of three inert C-H σ bonds all at once. Here, we show that a TiO2-CH3CN photocatalytic suspension system enables the insertion of dioxygen into one C(sp3)-C(sp3) bond of strained cycloparaffin derivatives, by which difunctionalized hydroxyketone products are obtained in a one-pot reaction. With the cleavage event to release strain as the directional driving force, as-designed photocatalytic reaction systems show 21 examples of β-hydroxyketone products with 31%–76% isolated yields for three-membered ring derivatives and 5 examples of γ-hydroxyketone products with 30%–63% isolated yields for four-membered ring substrates. 18O isotopic labeling experiments using 18O2, Ti18O2 and intentionally added H218O, respectively, indicated that both oxygen atoms of hydroxyketone products were exclusively from dioxygen, suggesting a previously unknown H+/TiO2-e? catalyzed arrangement pathway of the hydroperoxide intermediate to convert dioxygen into hydroxyketone units. [Figure not available: see fulltext.]
Diastereo- and Enantioselective Catalytic Radical Oxysulfonylation of Alkenes in β,γ-Unsaturated Ketoximes
Cheng, Gui-Juan,Gu, Qiang-Shuai,Li, Xi-Tao,Li, Zhong-Liang,Liu, Xin-Yuan,Lv, Ling,Wang, Ting,Xu, Guo-Xing,Ye, Liu,Zhang, Xinhao
supporting information, p. 1692 - 1706 (2020/07/08)
The asymmetric radical-initiated difunctionalization of internal alkenes, which creates two vicinal stereocenters, has been a significant synthetic challenge despite the tremendous progress achieved for terminal alkenes. This is attributable to the common
1,3 - Diphenyl -1 - propanol and preparation method thereof
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Paragraph 0063; 0072-0074, (2020/11/11)
The invention relates to 1, 3-diphenyl-1-propanol and a preparation method thereof and belongs to the technical field of chemical synthesis. The preparation method comprises that benzaldehyde and acetophenone undergo a catalytic reaction in the presence of dibenzylamine trifluoroacetate and a catalyst to produce 3-hydroxy-1, 3-diphenyl-1-propanone, and the 3-hydroxy-1, 3-diphenyl-1-propanone undergoes a Huang Minglon reduction reaction to produce 1, 3-diphenyl-1-propanol, wherein the catalyst is L-proline or D-proline. The preparation method has simple processes, realizes a low cost and prepares an optically pure product satisfying the requirements. The invention also relates to 1, 3-diphenyl-1-propanol obtained by the preparation method.
