2(1H)-Pyridinone,4-methoxy-(9CI)

Base Information

• Chemical Name: 2(1H)-Pyridinone,4-methoxy-(9CI)
• CAS No.: 52545-13-8
• Molecular Formula: C6H7NO2
• Molecular Weight: 125.127
• Hs Code.: 2933399090
• Mol file: 52545-13-8.mol

Synonyms:4-METHOXY-2(1H)-PYRIDINONE;

Chemical Property of 2(1H)-Pyridinone,4-methoxy-(9CI)

Chemical Property:

• Vapor Pressure: 3.21E-05mmHg at 25°C
• Melting Point: 101-102 °C
• Refractive Index: 1.526
• Boiling Point: 355.1oC at 760 mmHg
• PKA: 11.08±0.10(Predicted)
• Flash Point: 168.5oC
• PSA: 42.35000
• Density: 1.16g/cm3
• LogP: 0.79580
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

4-Methoxypyridin-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2(1H)-Pyridinone,4-methoxy-(9CI)

There total 11 articles about 2(1H)-Pyridinone,4-methoxy-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-methoxypyridine N-oxide (1122-96-9) → 4-methoxypyridin-2(1H)-one (52545-13-8)

Guidance literature:

4-methoxypyridine N-oxide; With acetic anhydride; Inert atmosphere; Reflux;

With methanol; water;

Reference yield: 66.0%

4-methoxypyridine N-oxide (1122-96-9) → 4-methoxypyridin-2-ol (52545-13-8,95907-06-5)

Guidance literature:

4-methoxypyridine N-oxide; With acetic anhydride; for 16h; Reflux;

In methanol; water; at 23 ℃; for 16h;

Reference yield: 51.0%

4-methoxy-3-(phenylsulfonyl)pyridin-2(1H)-one (870854-88-9) + methyl iodide (74-88-4) → 4-methoxypyridin-2(1H)-one (52545-13-8)

Guidance literature:

4-methoxy-3-(phenylsulfonyl)pyridin-2(1H)-one; With potassium tert-butylate; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; at 0 ℃;

methyl iodide; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tetlet.2005.09.095

upstream raw materials:

2,4-dimethoxypyridine

4-methoxypyridine

4-methoxypyridine N-oxide

5-methoxy-3-oxo-2-azabicyclo<2.2.0>hex-5-one

Downstream raw materials:

5-methoxy-2-azabicyclo<4.2.0>oct-4-en-3-one

6-methoxy-3-azabicyclo<4.2.0>-oct-4-en-2-one

6a-methoxy-1-methylene-1,2,2a,6a-tetrahydrocyclobutapyridin-3(4H)-one

4-Methoxy-3-trimethylsilanyl-1H-pyridin-2-one