Meso-1,3-diphenyl-1,3-propanediol

Base Information

• Chemical Name: Meso-1,3-diphenyl-1,3-propanediol
• CAS No.: 5381-86-2
• Molecular Formula: C15H16O2
• Molecular Weight: 228.291
• Mol file: 5381-86-2.mol

Synonyms:d,l-1,3-diphenylpropane-1,3-diol;1,3-diphenyl-1,3-propanediol;trans-1,3-diphenyl-1,3-propanediol;1,3-Diphenylpropane-1,3-diol;

Chemical Property of Meso-1,3-diphenyl-1,3-propanediol

Chemical Property:

• Melting Point: 108-109 °C(Solv: benzene (71-43-2))
• Boiling Point: 408.8±40.0 °C(Predicted)
• PKA: 13.81±0.20(Predicted)
• PSA: 40.46000
• Density: 1.164±0.06 g/cm3(Predicted)
• LogP: 2.84370

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Meso-1,3-diphenyl-1,3-propanediol

There total 103 articles about Meso-1,3-diphenyl-1,3-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-hydroxy-1,3-diphenylpropan-1-one (42052-51-7) → 1,3-diphenyl-1,3-propanediol (5355-61-3,5381-86-2,59825-14-8,77291-92-0,108391-15-7,5471-97-6)

Guidance literature:

With samarium diiodide; water; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

DOI:10.1021/ol047835p

Reference yield: 95.0%

3-hydroxy-1,3-diphenylpropan-1-one (42052-51-7) → (1R,3S)-1,3-diphenylpropane-1,3-diol (5381-86-2)

Guidance literature:

With diisopropoxytitanium(III) tetrahydroborate; In dichloromethane; at -20 ℃; for 0.0833333h;

DOI:10.1021/jo9902906

Reference yield: 95.0%

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-phenyl-1-phenylpropan-1-one (199999-46-7) → (1R,3S)-1,3-diphenylpropane-1,3-diol (5381-86-2)

Guidance literature:

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-phenyl-1-phenylpropan-1-one; With borane-THF; In tetrahydrofuran; at 0 - 25 ℃; Inert atmosphere;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 3h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1002/chem.201102081

upstream raw materials:

1-bromomercurio-2-hydroxy-2-phenylethane

benzaldehyde

3-hydroxy-1,3-diphenylpropan-1-one

1-phenyl-2-chloroethanol

Downstream raw materials:

1,3-diphenyl-1,3-dimethoxy propane

1,3-diphenyl-1-methoxy-3-hydroxy propane

1,3-diphenylpropanedione

1,3-Dibromo-1,3-diphenylpropane