199999-46-7

Upstream product

• 94-41-7 benzalacetophenone 
• 73183-34-3 bis(pinacol)diborane 
• 98-86-2 acetophenone 
• 100-52-7 benzaldehyde 
• 1083-30-3 dihydrochalcone 
• 64-17-5 ethanol 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 7732-18-5 water 

Downstream Products

• 42052-51-7 3-hydroxy-1,3-diphenylpropan-1-one 
• 1290145-60-6 8-(3-oxo-1,3-diphenylpropyl)hexahydro-1,3,2-oxazaborolo[2,3-b]-1,3,2-oxazaborol-4-ium-8-uide 
• 1290145-71-9 (3-oxo-1,3-diphenylpropyl)boronic acid 
• 1083-30-3 dihydrochalcone 
• 120-46-7 1,3-diphenylpropanedione 
• 5381-86-2 (1R,3S)-1,3-diphenylpropane-1,3-diol 
• 42052-51-7 (S)-3-hydroxy-1,3-diphenyl-propan-1-one 
• 42052-51-7 (R)-3-hydroxy-1,3-diphenylpropane-1-one 
• 108391-15-7 (1S,3S)-1,3-diphenylpropane-1,3-diol 
• 77291-92-0 (R,R)-1,3-diphenyl-1,3-propanediol 
• 1428331-71-8 3-fluoro-1,3-diphenylpropan-1-one 

Relevant academic research and scientific papers

Boration of an α,β-enone using a diboron promoted by a copper(I) - Phosphine mixture catalyst

The Cu(I)-catalyzed boration of an α,β-enone using a diboron is described. Combination of a Cu(I) salt and tributylphosphine is an effective catalyst system, though the individual use of Cu(I) and tributylphosphine is not active for the reaction. (C) 2000

Recyclable Copper Nanoparticles-Catalyzed Hydroboration of Alkenes and β-Borylation of α,β-Unsaturated Carbonyl Compounds with Bis(Pinacolato)Diboron

Nano-ferrite-supported Cu nanoparticles (Fe-dopamine-Cu NPs) catalyzed anti-Markovnikov-selective hydroboration of alkenes with B2pin2 is reported under mild reaction conditions. This protocol can be applied to a broad range of substrates with high functional group compatibility. In addition, we demonstrated the use of Fe-dopamine-Cu NPs as a catalyst for the β-borylation of α,β-unsaturated ketones and ester, providing alkylboronate esters in up to 98% yield. Reuse of the magnetically recyclable catalyst resulted in no significant loss of activity in up to five reaction runs for both systems. (Figure presented.).

Cellulosic CuI Nanoparticles as a Heterogeneous, Recyclable Catalyst for the Borylation of α,β-Unsaturated Acceptors in Aqueous Media

Abstract: We have demonstrated that cellulosic CuI nanoparticles could perform as an efficient heterogeneous catalyst for the synthesis of useful organoboron compounds. Desired β-borylation products were all obtained in good to excellent yields under mild

Configuration Sampling With Five-Membered Atropisomeric P,N-Ligands

Here we report a strategy for the systematic variation of atropisomeric C1-symmetric P,N ligands to incrementally change the position of the groups within the chiral pocket without modifying their steric parameters. More specifically, the effec

Method for preparing organoboron compound and beta-hydroxy compound by supported copper ion Y type molecular sieve catalyst

The invention relates to a method for preparing an organoboron compound and a beta-hydroxy compound by a supported copper ion Y type molecular sieve catalyst. The method for preparing the organoboroncompound mainly comprises the following steps: the step

Catalyst-free chemoselective conjugate addition and reduction of α,β-unsaturated carbonyl compounds: Via a controllable boration/protodeboronation cascade pathway

A novel, efficient transition-metal-free and controllable boration/protodeboronation strategy has been developed for the chemoselective conjugate addition and 1,4-reduction of α,β-unsaturated carbonyl compounds. Without any metal-catalyst or base, a series of β-boration products of α,β-unsaturated carbonyl compounds was easily obtained in moderate to excellent yields in a mixed solvent of ethanol and water. The presence of a catalytic amount of Cs2CO3 can effectively induce further protodeboronation reaction towards 1,4-reduction products at higher reaction temperature. Therefore, by slightly changing the reaction conditions, the boration or reduction products of α,β-unsaturated carbonyl compounds can be controllably obtained. Mechanistic studies revealed that Cs2CO3 played the key role in activating the protodeboronation step. This transition-metal-catalyst-free and product controllable method provides a useful and eco-friendly tool for the highly chemoselective preparation of the β-boration products and 1,4-reduction products of α,β-unsaturated carbonyl compounds.

Methods of preparing organic boron compound and beta-carbonyl compound by catalyzing copper ion loaded chitosan microspheres

The invention relates to methods of preparing an organic boron compound and a beta-carbonyl compound by catalyzing copper ion loaded chitosan microspheres. The preparation method of the organic boroncompound mainly comprises the following steps of A, addi

Cascade Reaction by Chemo- and Biocatalytic Approaches to Obtain Chiral Hydroxy Ketones and anti 1,3-Diols

A chemo- and biocatalytic cascade approach was applied for the stereoselective synthesis of hydroxy ketones and the corresponding 1,3-diols. A new class of tridentate N,N,O ligands was used with copper(II) complexes for the asymmetric β-borylation of α,β-unsaturated compounds. The complex containing ligand L5 emerged as the best performer, and it gave the organoborane derivatives with good ee values. The corresponding keto–alcohol compounds were then bioreduced by yeasts. The biotransformation set up with Rhodotorula rubra allowed (R)-keto–alcohols and (S,S)-diols to be obtained with up to 99 % ee and up to 99 % de in favor of the anti enantiomers.

Method for preparing organoboron compound under catalytic effect of chitosan immobilized copper and application

The invention discloses a method for preparing an organoboron compound under a catalytic effect of chitosan immobilized copper and an application. The method comprises the following steps: A) adding a chitosan immobilized copper catalyst and a ligand into a reaction tube and stirring; B) respectively continuously adding an initial raw material I and bisdiboron into a system in turn; C) stirring the whole reaction system and reacting under room temperature; D) after the reaction is ended, filtering the whole reaction system, washing with tetrahydrofuran, performing rotary evaporation and concentration on a filtrate, adopting a mixed solvent of ethyl acetate and petroleum ether at different ratios for performing column chromatography on the residues, separating and purifying, thereby acquiring a target product II. The silica gel is taken as a fixing phase for column chromatography. The invention also relates to the application of the prepared organoboron compound in compounding beta-hydroxy compound and anti-cancer drug molecules. The method is feasible; the operation is simple and convenient; the method is suitable for various substrates and can be used for successfully preparing the corresponding target compounds. The catalyst is low in dosage and is recyclable, is easily separated after the ending of the reaction, is free from metal residue and is suitable for large-scale production.

A green and recyclable chitosan supported catalyst for the borylation of α,β-unsaturated acceptors in water

We herein report a green and recyclable chitosan supported copper catalyst which is capable of catalyzing the borylation of α,β-unsaturated acceptors in water at room temperature. A broad substrate scope including chalcone derivatives, esters and nitriles have been explored. In all the cases, desired products were obtained in good to excellent yields. Remarkably, this chitosan supported catalyst could be recovered and reused for five times without any significant decrease of reactivity.