N-alpha-t-Butyloxycarbonyl-L-leucinyl-diazomethane, (S)-3-Boc-amino-1-diazo-5-methyl-2-hexanone

Base Information

Chemical Name:N-alpha-t-Butyloxycarbonyl-L-leucinyl-diazomethane, (S)-3-Boc-amino-1-diazo-5-methyl-2-hexanone
CAS No.:52716-48-0
Molecular Formula:C12H21N3O3
Molecular Weight:255.31344
Hs Code.:2927000090
Mol file:52716-48-0.mol

Synonyms:N-ALPHA-T-BUTYLOXYCARBONYL-L-LEUCINYL-DIAZOMETHANE, (S)-3-BOC-AMINO-1-DIAZO-5-METHYL-2-HEXANONE

Suppliers and Price of N-alpha-t-Butyloxycarbonyl-L-leucinyl-diazomethane, (S)-3-Boc-amino-1-diazo-5-methyl-2-hexanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of N-alpha-t-Butyloxycarbonyl-L-leucinyl-diazomethane, (S)-3-Boc-amino-1-diazo-5-methyl-2-hexanone

Chemical Property:

PSA：93.03000
LogP:3.25518

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-alpha-t-Butyloxycarbonyl-L-leucinyl-diazomethane, (S)-3-Boc-amino-1-diazo-5-methyl-2-hexanone

There total 5 articles about N-alpha-t-Butyloxycarbonyl-L-leucinyl-diazomethane, (S)-3-Boc-amino-1-diazo-5-methyl-2-hexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 52716-48-0
(3S)-3-<(tert-butoxy)carbonylamino>-1-diazo-5-methylhexan-2-one

Guidance literature:: N-tert-butoxycarbonyl-L-leucine; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at -15 ℃;

diazomethane; In tetrahydrofuran; dichloromethane; for 5h;
DOI:10.1002/1522-2675(200210)85:10<3313::AID-HLCA3313>3.0.CO;2-P

Reference yield:

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 75899-20-6,148854-05-1
(C₅H₉O₂)(NHCHCOO)(CH₂C₃H₇)(CO₂C₂H₅)

: 52716-48-0
(3S)-3-<(tert-butoxy)carbonylamino>-1-diazo-5-methylhexan-2-one

Guidance literature:: -5 deg C to room t.;
DOI:10.1002/hlca.19960790402

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 52716-48-0
(3S)-3-<(tert-butoxy)carbonylamino>-1-diazo-5-methylhexan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: NMM / tetrahydrofuran / 1 h / -25 °C

2: diethyl ether / 2 h / Ambient temperature

With 4-methyl-morpholine; In tetrahydrofuran; diethyl ether;
DOI:10.1016/S0040-4039(98)00675-3