2-Methoxy-4-methylbenzonitrile

Base Information

Chemical Name:2-Methoxy-4-methylbenzonitrile
CAS No.:53078-69-6
Molecular Formula:C9H9NO
Molecular Weight:147.17386
Hs Code.:2926909090
DSSTox Substance ID:DTXSID30500361
Wikidata:Q82351894
Mol file:53078-69-6.mol

Synonyms:2-METHOXY-4-METHYLBENZONITRILE;53078-69-6;MFCD11847156;4-methyl-2-methoxybenzonitrile;SCHEMBL2614475;DTXSID30500361;AFCQKLCTKJQOFR-UHFFFAOYSA-N;CL8173;AKOS011585701;DS-14970;SY110733;CS-0100569;FT-0714366;EN300-99692;A856536;Z972666194

Suppliers and Price of 2-Methoxy-4-methylbenzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Methoxy-4-methylbenzonitrile
100mg
$ 45.00

SynQuest Laboratories
2-Methoxy-4-methylbenzonitrile
1 g
$ 106.00

SynQuest Laboratories
2-Methoxy-4-methylbenzonitrile
5 g
$ 424.00

Matrix Scientific
2-Methoxy-4-methylbenzonitrile 95+%
250mg
$ 416.00

Crysdot
2-Methoxy-4-methylbenzonitrile 98%
10g
$ 337.00

ChemScene
2-Methoxy-4-methylbenzonitrile
5g
$ 226.00

ChemScene
2-Methoxy-4-methylbenzonitrile
10g
$ 361.00

Chemenu
2-Methoxy-4-methylbenzonitrile 95+%
10g
$ 318.00

American Custom Chemicals Corporation
2-METHOXY-4-METHYLBENZONITRILE 95.00%
1G
$ 1566.18

American Custom Chemicals Corporation
2-METHOXY-4-METHYLBENZONITRILE 95.00%
250MG
$ 1034.88

Total 26 raw suppliers

Chemical Property of 2-Methoxy-4-methylbenzonitrile

Chemical Property:

PSA：33.02000
LogP:1.87528
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:147.068413911
Heavy Atom Count:11
Complexity:170

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxy-4-methylbenzonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/38-43
Safety Statements: 26-36/37

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C=C1)C#N)OC

Technology Process of 2-Methoxy-4-methylbenzonitrile

There total 5 articles about 2-Methoxy-4-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 18495-14-2
2-hydroxy-4-methylbenzonitrile

: 74-88-4
methyl iodide

: 53078-69-6
2-methoxy-4-methylbenzonitrile

Guidance literature:: 2-hydroxy-4-methylbenzonitrile; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; at 60 ℃; for 5h; Inert atmosphere;
DOI:10.1039/d0ob00737d

Reference yield: 64.0%

: 557-21-1
zinc(II) cyanide

: 2-methoxy-4-methylphenyl methanesulfonate

: 53078-69-6
2-methoxy-4-methylbenzonitrile

Guidance literature:: With dmap; nickel(II) bromide dimethoxyethane; 1,4-di(diphenylphosphino)-butane; zinc; In acetonitrile; at 80 ℃; for 12h; Sealed tube; Inert atmosphere;
DOI:10.1021/acs.joc.8b02498

Reference yield:

: 108-39-4
3-methyl-phenol

: 53078-69-6
2-methoxy-4-methylbenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 24 h / 80 °C / Inert atmosphere

2.1: sodium hydroxide; water / 1,2-dichloro-ethane / 0.5 h / 80 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

3.2: 5 h / 60 °C / Inert atmosphere

With aluminum (III) chloride; water; potassium carbonate; sodium hydroxide; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1039/d0ob00737d