18495-14-2

Basic information

• Product Name: 2-HYDROXY-4-METHYL-BENZONITRILE
• Synonyms: 2-HYDROXY-4-METHYL-BENZONITRILE;2-Hydroxy-4-methyk-benzonitrile;Benzonitrile, 2-hydroxy-4-Methyl-
• CAS NO: 18495-14-2
• Molecular Formula: C₈H₇NO
• Molecular Weight: 133.15
• Product Categories: Aromatic Nitriles
• Mol File: 18495-14-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 87 °C
• Boiling Point: 286.047 °C at 760 mmHg
• Flash Point: 126.797 °C
• Appearance: /
• Density: 1.174 g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 7.28±0.10(Predicted)
• CAS DataBase Reference: 2-HYDROXY-4-METHYL-BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-4-METHYL-BENZONITRILE(18495-14-2)
• EPA Substance Registry System: 2-HYDROXY-4-METHYL-BENZONITRILE(18495-14-2)

Safety Data

• Hazardous Substances Data: 18495-14-2(Hazardous Substances Data)

Usage

General Description

2-Hydroxy-4-methyl-benzonitrile is a chemical compound with the molecular formula C8H7NO. It is a white crystalline solid and is used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. 2-HYDROXY-4-METHYL-BENZONITRILE is commonly used as an intermediate in the production of various chemicals, including dyes, pigments, and perfumes. It is also used as a building block in the synthesis of heterocyclic compounds and as a reagent in organic chemical reactions. Additionally, 2-hydroxy-4-methyl-benzonitrile has potential applications in the field of materials science and nanotechnology due to its unique chemical properties.

InChI:InChI=1/C8H7NO/c1-6-2-3-7(5-9)8(10)4-6/h2-4,10H,1H3

Upstream product

• 108-39-4 3-methyl-phenol 
• 698-27-1 4-methylsalicylaldehyde 
• 421551-85-1 2-acetoxy-4-methyl-benzonitrile 
• 84159-60-4 2-hydroxy-4-methylbenzaldehyde oxime 
• 676-58-4 methylmagnesium chloride 
• 190451-98-0 4-hydroxy-4-methyl-2-oxo-6-cyclohexenecarbonitrile 

Downstream Products

• 1268833-79-9 2-(5,6-dihydro-4H-1,3-oxazin-2-yl)-5-methylphenol 
• 704-45-0 2-methoxy-4-methylbenzoic acid 
• 877759-77-8 2-methoxy-4-methylbenzamide 
• 53078-69-6 2-methoxy-4-methylbenzonitrile 
• 105337-38-0 1-(2-hydroxy-4-methyl-phenyl)-3-methyl-butan-1-one 
• 24201-15-8 2-(4,5-dihydrooxazol-2-yl)-5-methylphenol 
• 357401-79-7 4-Methyl-2-{[(1R)-3-(methylamino)-1-phenylpropyl]oxy}benzonitrile hydrochloride 

Relevant articles and documents

Lewis acid-promoted site-selective cyanation of phenols

An efficient Lewis acid-promoted site-selective electrophilic cyanation of 3-substituted and 3,4-disubstituted phenols has been developed. The cyanation reactions using MeSCN as the cyanating reagent proceeded efficiently to afford a wide range of 2-hydroxybenzonitriles with high efficiency and excellent regioselectivity. This protocol could provide a practical method for the synthesis and modification of biologically active molecules.

Preparation method for piperidine derivative

The invention discloses a preparation method for a piperidine derivative, i.e., 4-((2-(aminomethyl)-5-methylphenoxyl)methyl)piperidine-1-t-butyl formate. According to the invention, 2-hydroxy-4-methylbenzaldehyde is used as a starting material and subject

A catalytic route to ampakines and their derivatives

A catalytic domino reaction that efficiently provides access to an important class of heterocycles, the ampakines, is reported. Our approach is based on the cobalt-catalyzed hydroformylation of dihydrooxazines and allows for the facile synthesis of the pharmaceutically interesting compound CX-614 and related substances.