3',5'-DIMETHYL-2'-HYDROXYPROPIOPHENONE

Base Information

• Chemical Name: 3',5'-DIMETHYL-2'-HYDROXYPROPIOPHENONE
• CAS No.: 5570-72-9
• Molecular Formula: C11H14O2
• Molecular Weight: 178.231
• Mol file: 5570-72-9.mol

Synonyms:3',5'-DIMETHYL-2'-HYDROXYPROPIOPHENONE

Chemical Property of 3',5'-DIMETHYL-2'-HYDROXYPROPIOPHENONE

Chemical Property:

• Melting Point: 54°C
• PSA: 37.30000
• LogP: 2.60170

Purity/Quality:

99%min ^*data from raw suppliers

1-(2-Hydroxy-3,5-dimethylphenyl)propan-1-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3',5'-DIMETHYL-2'-HYDROXYPROPIOPHENONE

There total 5 articles about 3',5'-DIMETHYL-2'-HYDROXYPROPIOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

1,1,3,3-tetraethoxy-2-methyl-propane (10602-37-6) + 4-ethyl-1-methyl-1,3-bis(trimethylsilyloxy)-1,3-butadiene (88083-83-4) → 1-(2-hydroxy-3,5-dimethylphenyl)-1-propanone (5570-72-9)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at -78 - 20 ℃; for 14h;

DOI:10.1021/jo070847e

Reference yield: 17.0%

propionic acid-(2-bromo-4,6-dimethyl-phenyl ester) (106161-27-7) → 1-(2-hydroxy-3,5-dimethylphenyl)-1-propanone (5570-72-9)

Guidance literature:

With sec.-butyllithium; In tetrahydrofuran; diethyl ether; hexane; at -95 - -78 ℃; for 1h;

DOI:10.1021/jo00378a044

Reference yield:

2,4-dimethylphenyl propanoate (51233-78-4) → 1-(2-hydroxy-3,5-dimethylphenyl)-1-propanone (5570-72-9)

Guidance literature:

With aluminium trichloride; at 130 - 140 ℃;

DOI:10.1039/jr9360000215

upstream raw materials:

2,4-dimethylphenyl propanoate

propionic acid-(2-bromo-4,6-dimethyl-phenyl ester)

1,1,3,3-tetraethoxy-2-methyl-propane

4-ethyl-1-methyl-1,3-bis(trimethylsilyloxy)-1,3-butadiene

Downstream raw materials:

2,4-Dimethyl-6-<1-hydroxy-propyl>-anisol

2,4-Dimethyl-6-propionyl-anisol

Refernces

• 1、 Mamat, Constantin,Buettner, Stefan,Trabhardt, Tiana,Fischer, Christine,Langer, Peter. "Regioselective synthesis of 5-alkylsalicylates, 5-alkyl-2-hydroxy- acetophenones, and 5-alkyl-2-hydroxy-benzophenones by [3 + 3] cyclization of 1,3-bis(silyl enol ethers) with 2-alkyl-1,1,3,3-tetraethoxypropanes". . p. 6273 - 6275. Retrieved 2008/02/10.