5-Pyrimidinecarboxylic acid, 2-methyl-, methyl ester (7CI,8CI,9CI)

Base Information

• Chemical Name: 5-Pyrimidinecarboxylic acid, 2-methyl-, methyl ester (7CI,8CI,9CI)
• CAS No.: 5571-03-9
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.15062
• Hs Code.: 2933599090
• Mol file: 5571-03-9.mol

Synonyms:5-Pyrimidinecarboxylic acid, 2-methyl-, methyl ester (7CI,8CI,9CI)

Chemical Property of 5-Pyrimidinecarboxylic acid, 2-methyl-, methyl ester (7CI,8CI,9CI)

Chemical Property:

• PSA: 52.08000
• LogP: 0.57160
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl 2-methylpyrimidine-5-carboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Pyrimidinecarboxylic acid, 2-methyl-, methyl ester (7CI,8CI,9CI)

There total 9 articles about 5-Pyrimidinecarboxylic acid, 2-methyl-, methyl ester (7CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

acetamidine hydrochloride (124-42-5) + sodium (1Z)-2-(dimethoxymethyl)-3-methoxy-3-oxoprop-1-en-1-olate → methyl 2-methylpyrimidine-5-carboxylate (5571-03-9)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 1h;

DOI:10.1055/s-2002-25767

Reference yield: 69.0%

acetamidine (143-37-3) + methyl 1,2,3-triazine-5-carboxylate → methyl 2-methylpyrimidine-5-carboxylate (5571-03-9)

Guidance literature:

In acetonitrile; at 23 ℃; for 0.0833333h; Inert atmosphere;

DOI:10.1021/acs.joc.1c01553

Reference yield: 68.0%

methyl 1,2,3-triazine-5-carboxylate + O-ethyl acetimidate (1000-84-6) → methyl 2-methylpyrimidine-5-carboxylate (5571-03-9)

Guidance literature:

In acetonitrile; at 22 ℃; for 0.25h; regiospecific reaction;

DOI:10.1021/ja204856a

upstream raw materials:

acetamidine hydrochloride

methyl pyrazole-4-carboxylate

methyl 1-trityl-1H-pyrazole-4-carboxylate

acetamidine