6-METHOXY-2-METHYLQUINOLIN-4-OL

Base Information

• Chemical Name: 6-METHOXY-2-METHYLQUINOLIN-4-OL
• CAS No.: 58596-37-5
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.214
• Mol file: 58596-37-5.mol

Synonyms:6-METHOXY-2-METHYLQUINOLIN-4(1H)-ONE;6-METHOXY-2-METHYLQUINOLIN-4-OL;6-METHOXY-2-METHYL-4(1H)-QUINOLINONE;6-METHOXY-2-METHYL-4-QUINOLINOL;4-HYDROXY-6-METHOXY-2-METHYLQUINOLINE;AURORA 18754;IFLAB-BB F1920-0020

Chemical Property of 6-METHOXY-2-METHYLQUINOLIN-4-OL

Chemical Property:

• Refractive Index: 1.557
• Boiling Point: 328.5°Cat760mmHg
• Flash Point: 152.4°C
• PSA: 42.35000
• Density: 1.153g/cm³
• LogP: 2.25740
• Storage Temp.: Room temperature.

Purity/Quality:

98.5% ^*data from raw suppliers

6-Methoxy-2-methylquinolin-4(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-METHOXY-2-METHYLQUINOLIN-4-OL

There total 6 articles about 6-METHOXY-2-METHYLQUINOLIN-4-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl 3-((4-methoxyphenyl)amino)but-2-enoate (33240-23-2) → 6-methoxy-2-methylquinolin-4(1H)-one (58596-37-5)

Guidance literature:

for 0.0333333h; microwave irradiation;

Reference yield: 90.0%

ethyl acetoacetate (141-97-9) + 4-methoxy-aniline (104-94-9) → 6-methoxy-2-methylquinolin-4(1H)-one (58596-37-5)

Guidance literature:

With NaHSO₄ on SiO₂ solid support; for 0.0833333h; Microwave irradiation; Neat (no solvent);

DOI:10.5012/jkcs.2010.54.6.723

Reference yield: 79.0%

ethyl (Z)-3-(4-methoxyanilino)-2-butenoate (33240-23-2,66558-24-5) → 6-methoxy-2-methylquinolin-4(1H)-one (58596-37-5)

Guidance literature:

In diphenylether; at 120 - 260 ℃; Inert atmosphere;

DOI:10.3987/COM-09-11868

upstream raw materials:

ethyl 3-((4-methoxyphenyl)amino)but-2-enoate

ethyl (Z)-3-(4-methoxyanilino)-2-butenoate

ethyl acetoacetate

4-methoxy-aniline

Downstream raw materials:

4-chloro-6-methoxy-2-methylquinoline

4-{[(4-tert-butyl)phenyl]methoxy}-6-methoxy-2-methylquinoline

4-{[(4-tert-butyl)phenyl]methylthio}-6-methoxy-2-methylquinoline

C₁₉H₁₆F₃NOS

Refernces

• 1、 Ao, Mingtao,Pan, Zhenrui,Qian, Yuqing,Tang, Bowen,Feng, Zeming,Fang, Hua,Wu, Zhen,Chen, Jingwei,Xue, Yuhua,Fang, Meijuan. "Design, synthesis, and biological evaluation of AV6 derivatives as novel dual reactivators of latent HIV-1". . p. 17279 - 17292. Retrieved 2018/05/29.
• 2、 Bhupathi, Raja S.,Bandi, Madhu,Ch, Venkata Ramana Reddy,Rama Devi,Dubey. "Green and Efficient Synthesis of 4-Heteryl-Quinolines and Their Antibacterial Evaluations". . p. 1236 - 1241. Retrieved 2017/03/27.