4-(Difluoromethoxy)-N-methylaniline

Base Information

Chemical Name:4-(Difluoromethoxy)-N-methylaniline
CAS No.:638192-10-6
Molecular Formula:C8H9F2NO
Molecular Weight:173.162
Hs Code.:2922199090
DSSTox Substance ID:DTXSID10592941
Wikidata:Q82487309
Mol file:638192-10-6.mol

Synonyms:4-(Difluoromethoxy)-N-methylaniline;638192-10-6;Benzenamine, 4-(difluoromethoxy)-N-methyl- (9CI);BENZENAMINE, 4-(DIFLUOROMETHOXY)-N-METHYL-;4-(difluoromethoxy)-N-methyl-aniline;SCHEMBL3113605;DTXSID10592941;AKOS009050403;(4-difluoromethoxy-phenyl)-methyl-amine;DB-273803;EN300-1254096;A1-24052

Suppliers and Price of 4-(Difluoromethoxy)-N-methylaniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-(DIFLUOROMETHOXY)-N-METHYL-BENZENAMINE 95.00%
5MG
$ 497.88

Alichem
4-(Difluoromethoxy)-N-methylbenzenamine
500mg
$ 806.85

Alichem
4-(Difluoromethoxy)-N-methylbenzenamine
250mg
$ 499.20

Alichem
4-(Difluoromethoxy)-N-methylbenzenamine
1g
$ 1579.40

A1 Biochem Labs
4-(Difluoromethoxy)-N-methylaniline 95%
2.5 g
$ 1150.00

Total 3 raw suppliers

Chemical Property of 4-(Difluoromethoxy)-N-methylaniline

Chemical Property:

Boiling Point:230.9±35.0 °C(Predicted)
PKA:4.32±0.19(Predicted)
PSA：21.26000
Density:1.201±0.06 g/cm3(Predicted)
LogP:2.40270
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:173.06522023
Heavy Atom Count:12
Complexity:124

Purity/Quality:

99%+ ^*data from raw suppliers

4-(DIFLUOROMETHOXY)-N-METHYL-BENZENAMINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC1=CC=C(C=C1)OC(F)F

Technology Process of 4-(Difluoromethoxy)-N-methylaniline

There total 3 articles about 4-(Difluoromethoxy)-N-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 638192-11-7
ethyl(4-difluoromethoxyphenyl)carbamate

: 638192-10-6
4-(difluoromethoxy)-N-methylaniline

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 - 50 ℃; for 22h;

Reference yield: 57.0%

: C₉H₁₁F₂NO

: 638192-10-6
4-(difluoromethoxy)-N-methylaniline

: C₉H₉F₂NO₂

Guidance literature:: With sodium tetrafluoroborate; [Cu(salicylate)₂(NCMe)]₂; tetrabutyl-ammonium chloride; oxygen; In acetonitrile; at 40 ℃; Schlenk technique;
DOI:10.1002/cctc.201901962

Reference yield:

: 22236-10-8
4-difluoromethoxyaniline

: 638192-10-6
4-(difluoromethoxy)-N-methylaniline

Guidance literature:: Multi-step reaction with 2 steps

1: DIEA; DMAP / tetrahydrofuran / 25 °C

2: LiAlH₄ / tetrahydrofuran / 60 °C

With dmap; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2006.02.044