5(1H)-Indolizinone, hexahydro-8-hydroxy-8-methyl-6-(2-methylpropylidene)-, (6Z,8S,8aS)- (9CI)

Base Information

Chemical Name:5(1H)-Indolizinone, hexahydro-8-hydroxy-8-methyl-6-(2-methylpropylidene)-, (6Z,8S,8aS)- (9CI)
CAS No.:516479-33-7
Molecular Formula:C13H21NO2
Molecular Weight:223.31134
Hs Code.:
Mol file:516479-33-7.mol

Synonyms:5(1H)-Indolizinone, hexahydro-8-hydroxy-8-methyl-6-(2-methylpropylidene)-, (6Z,8S,8aS)- (9CI)

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Chemical Property of 5(1H)-Indolizinone, hexahydro-8-hydroxy-8-methyl-6-(2-methylpropylidene)-, (6Z,8S,8aS)- (9CI)

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Technology Process of 5(1H)-Indolizinone, hexahydro-8-hydroxy-8-methyl-6-(2-methylpropylidene)-, (6Z,8S,8aS)- (9CI)

There total 4 articles about 5(1H)-Indolizinone, hexahydro-8-hydroxy-8-methyl-6-(2-methylpropylidene)-, (6Z,8S,8aS)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78-84-2
isobutyraldehyde

: (5S,6S)-3-(diethoxyphosphonyl)-5-hydroxy-5-methylazabicyclo[4.3.0]nonan-2-one

: (8S,8aS)-8-Methyl-6-[2-methyl-prop-(E)-ylidene]-octahydro-indolizin-8-ol

: 516479-33-7
(3Z)-(5S,6S)-5-hydroxy-3-isobutylidene-5-methylazabicyclo[4.3.0]nonan-2-one

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 3h;
DOI:10.1002/1099-0690(200210)2002:19<3315::AID-EJOC3315>3.0.CO;2-2

Reference yield:

: 494225-08-0
(8S,8aS)-8-methyl-8-(trimethylsilyloxy)hexahydroindolizin-5(1H)-one

: 516479-33-7
(3Z)-(5S,6S)-5-hydroxy-3-isobutylidene-5-methylazabicyclo[4.3.0]nonan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: LDA / tetrahydrofuran / 0.83 h / -78 °C

2: 533.7 mg / LDA / tetrahydrofuran / -78 °C

3: 100 percent / HCl / methanol / 1 h / 20 °C

4: LDA / tetrahydrofuran / 3 h / -78 °C

With hydrogenchloride; lithium diisopropyl amide; In tetrahydrofuran; methanol;
DOI:10.1002/1099-0690(200210)2002:19<3315::AID-EJOC3315>3.0.CO;2-2

Reference yield:

: Phosphoric acid diethyl ester (8S,8aS)-8-methyl-8-trimethylsilanyloxy-1,2,3,7,8,8a-hexahydro-indolizin-5-yl ester

: 516479-33-7
(3Z)-(5S,6S)-5-hydroxy-3-isobutylidene-5-methylazabicyclo[4.3.0]nonan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 533.7 mg / LDA / tetrahydrofuran / -78 °C

2: 100 percent / HCl / methanol / 1 h / 20 °C

3: LDA / tetrahydrofuran / 3 h / -78 °C

With hydrogenchloride; lithium diisopropyl amide; In tetrahydrofuran; methanol;
DOI:10.1002/1099-0690(200210)2002:19<3315::AID-EJOC3315>3.0.CO;2-2