2-5-dimethoxybutyrophenone

Base Information

• Chemical Name: 2-5-dimethoxybutyrophenone
• CAS No.: 54419-64-6
• Molecular Formula: C12H16O3
• Molecular Weight: 208.257
• Hs Code.: 2914509090
• Mol file: 54419-64-6.mol

Synonyms:2-5-dimethoxybutyrophenone;1-(2,5-dimethoxyphenyl)butan-1-one

Chemical Property of 2-5-dimethoxybutyrophenone

Chemical Property:

• PSA: 35.53000
• LogP: 2.68660

Purity/Quality:

98% ^*data from raw suppliers

1-(2,5-Dimethoxy-phenyl)-butan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-5-dimethoxybutyrophenone

There total 5 articles about 2-5-dimethoxybutyrophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2,5-dimethoxybenzonitrile (5312-97-0) + 1-propylmagnesium chloride (2234-82-4) → 1-(2,5-dimethoxyphenyl) butan-1-one (54419-64-6)

Guidance literature:

2,5-dimethoxybenzonitrile; 1-propylmagnesium chloride; In diethyl ether; at 40 ℃; for 2h;

With hydrogenchloride; water; In diethyl ether; at 23 ℃; for 16h;

Reference yield:

butyryl chloride (141-75-3) + 1,4-dimethoxybezene (150-78-7) → 1-(2,5-dimethoxyphenyl) butan-1-one (54419-64-6)

Guidance literature:

With aluminium trichloride; nitrobenzene; zuletzt unter Erwaermen;

Reference yield:

1-(2,5-dimethoxy-phenyl)-3-piperidin-1-yl-butan-1-one (2081-82-5) → 1-(2,5-dimethoxyphenyl) butan-1-one (54419-64-6)

Guidance literature:

With hydrogen; platinum; In ethanol;

DOI:10.1248/cpb.22.1348

upstream raw materials:

butyryl chloride

1,4-dimethoxybezene

butanoic acid anhydride

propyl cyanide

Downstream raw materials:

2-butyl-1,4-dimethoxy-benzene

(R)-(2,5-Dimethoxyphenyl)propylcarbinol

4-butyl-2,5-dimethoxyamphetamine

1-(2,5-Dimethoxy-4-butylphenyl)-2-nitro-1-propen

Refernces

• 1、 -. "PYRAZOLYL-BASED CARBOXAMIDES II AS CRAC CHANNEL INHIBITORS". Page/Page column 71. . Retrieved 2014/07/23.
• 2、 Shulgin,Dyer. "Psychotomimetic phenylisopropylamines. 5. 4 alkyl 2,5 dimethoxyphenylisopropylamines". . p. 1201 - 1204. Retrieved 2007/10/06.