BZ-NLE-OH

Base Information

• Chemical Name: BZ-NLE-OH
• CAS No.: 54430-46-5
• Molecular Formula: C13H17NO3
• Molecular Weight: 235.283
• Hs Code.: 2924299090
• Mol file: 54430-46-5.mol

Synonyms:N-ALPHA-BENZOYL-L-NORLEUCINE;N-ALPHA-BENZOYL-2-AMINO-CAPROIC ACID;BENZOYL-L-2-AMINOHEXANOIC ACID;BENZOYL-L-NORLEUCINE;BZ-NLE-OH;BZO-ACPO(2)-OH;BZO-AHX(2)-OH;BZO-NLE-OH

Chemical Property of BZ-NLE-OH

Chemical Property:

• Vapor Pressure: 1.71E-09mmHg at 25°C
• Refractive Index: 1.535
• Boiling Point: 466.2°C at 760 mmHg
• Flash Point: 235.8°C
• PSA: 66.40000
• Density: 1.134g/cm³
• LogP: 2.45070

Purity/Quality:

98.5% ^*data from raw suppliers

Bz-Nle-OH 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BZ-NLE-OH

There total 5 articles about BZ-NLE-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(S)-N-(1-furan-2-yl-pentyl)benzamide (1469876-47-8) → N-(benzoyl)-D,L-norleucine (54430-46-5)

Guidance literature:

With sodium periodate; ruthenium(III) trichloride hydrate; water; In dichloromethane; acetonitrile; at 20 ℃; for 2h;

DOI:10.3906/kim-1302-71

Reference yield:

L-Norleucine (327-57-1) + benzoyl chloride (98-88-4) → N-(benzoyl)-D,L-norleucine (54430-46-5)

Guidance literature:

DOI:10.1246/cl.1994.831

Reference yield:

C15H26N2O2 → N-(benzoyl)-D,L-norleucine (54430-46-5)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap; triethylamine / dichloromethane / 20 °C

2: samarium diiodide; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran / 20 °C / Inert atmosphere

3: ruthenium(III) trichloride hydrate; sodium periodate; water / dichloromethane; acetonitrile / 2 h / 20 °C

With dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium periodate; samarium diiodide; ruthenium(III) trichloride hydrate; water; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.3906/kim-1302-71

upstream raw materials:

L-Norleucine

benzoyl chloride

C₂₂H₃₀N₂O₃

(S)-N-(1-furan-2-yl-pentyl)benzamide

Refernces

• 1、 Enders, Dieter,Del Signore, Giuseppe,Raabe, Gerhard. "Asymmetric synthesis of α-(heteroaryl)alkylamines and α-amino acids via nucleophilic 1,2-addition of lithiated heterocycles to aldehyde SAMP-hydrazones". . p. 492 - 518. Retrieved 2013/08/23.
• 2、 -. "HYDROXY SUBSTITUTED UREIDO AMINO AND IMINO ACIDS". . . Retrieved 2008/06/13.