3-Methoxy-1,3,4-trimethylpiperazine-2,5-dione

Base Information

Chemical Name:3-Methoxy-1,3,4-trimethylpiperazine-2,5-dione
CAS No.:519141-18-5
Molecular Formula:C8H14N2O3
Molecular Weight:186.21
Hs Code.:
DSSTox Substance ID:DTXSID70479825
Nikkaji Number:J1.857.115C
Mol file:519141-18-5.mol

Synonyms:519141-18-5;3-METHOXY-1,3,4-TRIMETHYLPIPERAZINE-2,5-DIONE;2,5-Piperazinedione,3-methoxy-1,3,4-trimethyl-(9CI);DTXSID70479825

Suppliers and Price of 3-Methoxy-1,3,4-trimethylpiperazine-2,5-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AccelPharmtech
3-methoxy-1,3,4-trimethyl-2,5-Piperazinedione 97.00%
25G
$ 12900.00

AccelPharmtech
3-methoxy-1,3,4-trimethyl-2,5-Piperazinedione 97.00%
5G
$ 6840.00

Total 1 raw suppliers

Chemical Property of 3-Methoxy-1,3,4-trimethylpiperazine-2,5-dione

Chemical Property:

PSA：49.85000
LogP:-0.84480
XLogP3:-0.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:186.10044231
Heavy Atom Count:13
Complexity:254

Purity/Quality:: 3-methoxy-1,3,4-trimethyl-2,5-Piperazinedione 97.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(C(=O)N(CC(=O)N1C)C)OC

Technology Process of 3-Methoxy-1,3,4-trimethylpiperazine-2,5-dione

There total 12 articles about 3-Methoxy-1,3,4-trimethylpiperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 519141-24-3
3-carboxyl-1,3,4-trimethylpiperazine-2,5-dione

: 67-56-1
methanol

: 519141-18-5
3-methoxy-1,3,4-trimethylpiperazine-2,5-dione

Guidance literature:: 3-carboxyl-1,3,4-trimethylpiperazine-2,5-dione; With [bis(acetoxy)iodo]benzene; iodine; In dichloromethane; for 0.166667h;

methanol; In dichloromethane; for 16h;
DOI:10.1016/j.tet.2005.06.084

Reference yield: 77.0%

: 67-56-1
methanol

: 1-ethyl-4-methyl-3,6-dioxo-piperazine-2-carboxylic acid

: 519141-18-5
3-methoxy-1,3,4-trimethylpiperazine-2,5-dione

Guidance literature:: 1-ethyl-4-methyl-3,6-dioxo-piperazine-2-carboxylic acid; With [bis(acetoxy)iodo]benzene; iodine;

methanol;
DOI:10.1016/S0040-4039(02)02571-6

Reference yield:

: 865879-17-0
benzyl N-[N-t-butoxycarbonylsarcosyl]-2-benzyloxycarbonylglycinate

: 519141-18-5
3-methoxy-1,3,4-trimethylpiperazine-2,5-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: TFA / CHCl₃ / 16 h / 20 °C

2.1: 4.59 g / toluene / 24 h / Heating

3.1: 89 percent / K₂CO₃ / acetone / 48 h / Heating

4.1: 92 percent / NaH / dimethylformamide / 24 h / 0 °C

5.1: 100 percent / H₂ / Pd/C / methanol / 1 h

6.1: I₂; diacetoxyiodobenzene / CH₂Cl₂ / 0.17 h

6.2: 77 percent / CH₂Cl₂ / 16 h

With [bis(acetoxy)iodo]benzene; hydrogen; iodine; sodium hydride; potassium carbonate; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/j.tet.2005.06.084