Benzofuran-2-carboxamide

Base Information

• Chemical Name: Benzofuran-2-carboxamide
• CAS No.: 50342-50-2
• Molecular Formula: C9H7NO2
• Molecular Weight: 161.16
• European Community (EC) Number: 659-540-6
• DSSTox Substance ID: DTXSID70350741
• Nikkaji Number: J1.619.384D
• Wikidata: Q82126832
• Mol file: 50342-50-2.mol

Synonyms:Benzofuran-2-carboxamide;50342-50-2;2-BENZOFURANCARBOXAMIDE;1-benzofuran-2-carboxamide;benzo[b]furan-2-carboxamide;benzofuran-2-amide;2-benzo[b]furancarboxamide;Oprea1_350766;SCHEMBL649402;DTXSID70350741;2-Benzofurancarboxamide(7ci,9ci);Benzofuran-2-carboxylic acid amide;MFCD00092614;AKOS000299298;TS-02140;BB 0244289;CS-0453128;FT-0711581;A871598

Chemical Property of Benzofuran-2-carboxamide

Chemical Property:

• Melting Point: 158-159 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 361.7±15.0 °C(Predicted)
• PKA: 15.62±0.30(Predicted)
• PSA: 57.22000
• Density: 1.288±0.06 g/cm3(Predicted)
• LogP: 2.41590
• Storage Temp.: 2-8°C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 161.047678466
• Heavy Atom Count: 12
• Complexity: 193

Purity/Quality:

97% ^*data from raw suppliers

2-BENZOFURANCARBOXAMIDE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=C(O2)C(=O)N

Technology Process of Benzofuran-2-carboxamide

There total 17 articles about Benzofuran-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-benzofuroyl chloride (41717-28-6) → benzofuran-2-carboxamide (50342-50-2)

Guidance literature:

With ammonia; In tetrahydrofuran; at -50 ℃; for 1h;

DOI:10.1021/jm0211220

Reference yield: 88.0%

ethyl coumarilate (3199-61-9) → benzofuran-2-carboxamide (50342-50-2)

Guidance literature:

With ammonia; calcium chloride; In methanol; at 80 ℃; for 24h; under 1275.13 Torr; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.05.075

Reference yield: 81.0%

2-(β,β-dibromovinyl)phenol (91703-34-3) + molybdenum hexacarbonyl (13939-06-5,199620-15-0) → benzofuran-2-carboxamide (50342-50-2)

Guidance literature:

With 1,10-Phenanthroline; ammonium hydroxide; copper dichloride; In propan-1-ol; water; at 100 ℃; for 8h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.0c01620

upstream raw materials:

2-benzofuroyl chloride

Benzofuran-2-carboxylic acid

oxalyl dichloride

7-methoxy-3-benzofuranone

Downstream raw materials:

benzofuran-2-ylmethanamine