Ethanone, 1-(4-ethyl-2-pyridinyl)- (9CI)

Base Information

• Chemical Name: Ethanone, 1-(4-ethyl-2-pyridinyl)- (9CI)
• CAS No.: 59576-27-1
• Molecular Formula: C9H11NO
• Molecular Weight: 149.18974
• Mol file: 59576-27-1.mol

Synonyms:Ethanone, 1-(4-ethyl-2-pyridinyl)- (9CI)

Chemical Property of Ethanone, 1-(4-ethyl-2-pyridinyl)- (9CI)

Chemical Property:

• Boiling Point: 100 - 101 °C (11 mmHg)
• PSA: 29.96000
• LogP: 1.84660

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-(4-ethyl-2-pyridinyl)- (9CI)

There total 5 articles about Ethanone, 1-(4-ethyl-2-pyridinyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N,N-dimethyl acetamide (127-19-5,116057-81-9) + 2-bromo-4-ethylpyridine (54453-91-7) → 2-acetyl-4-ethylpyridine (59576-27-1)

Guidance literature:

With n-butyllithium; In diethyl ether; hexane;

DOI:10.1021/ja9623626

Reference yield:

2-cyano-4-ethylpyridine (92486-38-9) + methyl magnesium iodide (917-64-6) → 2-acetyl-4-ethylpyridine (59576-27-1)

Guidance literature:

With diethyl ether; benzene; Und folgenden Hydrolisieren;

DOI:10.1021/ja01603a036

Reference yield:

4-Ethylpyridine (536-75-4,151103-55-8) → 2-acetyl-4-ethylpyridine (59576-27-1)

Guidance literature:

Multi-step reaction with 4 steps

1: NaNH₂; N,N-dimethyl-aniline / 130 - 140 °C

2: bromine; aqueous sodium nitrite solution; aqueous hydrobromic acid

3: zuletzt unter vermindertem Druck

4: diethyl ether; benzene / Und folgenden Hydrolisieren

With diethyl ether; hydrogen bromide; bromine; sodium amide; N,N-dimethyl-aniline; sodium nitrite; benzene;

DOI:10.1021/ja01603a036

upstream raw materials:

2-cyano-4-ethylpyridine

methyl magnesium iodide

N,N-dimethyl acetamide

2-bromo-4-ethylpyridine

Refernces

• 1、 Constable,Heirtzler,Neuburger,Zehnder. "Steric control of directional isomerism in dicopper(I) helicates of asymmetrically substituted 2,2':6',2':2,6'-quaterpyridine derivatives". . p. 5606 - 5617. Retrieved 2007/10/03.