(1R,2R)-[1,2-Cyclohexanediamino-N,N'-bis(4-bromobenzyl)allylchlorosilane

Base Information

Chemical Name:(1R,2R)-[1,2-Cyclohexanediamino-N,N'-bis(4-bromobenzyl)allylchlorosilane
CAS No.:546084-25-7
Molecular Formula:C23H27Br2ClN2Si
Molecular Weight:554.827
Hs Code.:
European Community (EC) Number:633-708-9
DSSTox Substance ID:DTXSID30439485
Nikkaji Number:J1.889.817I
Wikidata:Q76415622
Mol file:546084-25-7.mol

Synonyms:546084-25-7;(1R,2R)-[1,2-Cyclohexanediamino-N,N'-bis(4-bromobenzyl)allylchlorosilane;(3Ar,7aR)-1,3-bis[(4-bromophenyl)methyl]-2-chloro-2-prop-2-enyl-3a,4,5,6,7,7a-hexahydrobenzo[d][1,3,2]diazasilole;MFCD10567380;SCHEMBL13839731;DTXSID30439485;(1R,2R)-[1,2-Cyclohexanediamino-N,N'-bis(4-bromobenzyl)allylchlorosilane,min.98%;(3aR,7aR)-1,3-Bis(4-bromobenzyl)-2-allyl-2-chloro-1,3-diaza-2-silahydrindane;(R,R)-1,3-Bis[(4-bromophenyl)methyl]-2-chlorooctahydro-2-allyl-1H-1,3,2-benzodiazasilole, 95%

Suppliers and Price of (1R,2R)-[1,2-Cyclohexanediamino-N,N'-bis(4-bromobenzyl)allylchlorosilane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Strem Chemicals
(1R,2R)-[1,2-Cyclohexanediamino-N,N'-bis(4-bromobenzyl)allylchlorosilane, min. 98%
1g
$ 261.00

Strem Chemicals
(1R,2R)-[1,2-Cyclohexanediamino-N,N'-bis(4-bromobenzyl)allylchlorosilane, min. 98%
250mg
$ 87.00

American Custom Chemicals Corporation
(R,R)-1,3-BIS[(4-BROMOPHENYL)METHYL]-2-CHLOROOCTAHYDRO-2-ALLYL-1H-1,3,2-BENZODIAZASILOLE 95.00%
5G
$ 1193.96

American Custom Chemicals Corporation
(R,R)-1,3-BIS[(4-BROMOPHENYL)METHYL]-2-CHLOROOCTAHYDRO-2-ALLYL-1H-1,3,2-BENZODIAZASILOLE 95.00%
1G
$ 525.00

Total 6 raw suppliers

Chemical Property of (1R,2R)-[1,2-Cyclohexanediamino-N,N'-bis(4-bromobenzyl)allylchlorosilane

Chemical Property:

Boiling Point:561.2±60.0 °C(Predicted)
PKA:6.37±0.20(Predicted)
PSA：6.48000
Density:1.48±0.1 g/cm3(Predicted)
LogP:7.08010
Storage Temp.:2-8°C
Sensitive.:moisture sensitive, store cold
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:553.99783
Heavy Atom Count:29
Complexity:509

Purity/Quality:

98%,99%, ^*data from raw suppliers

(1R,2R)-[1,2-Cyclohexanediamino-N,N'-bis(4-bromobenzyl)allylchlorosilane, min. 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s): F,C
Hazard Codes:F,C
Statements: 15-34
Safety Statements: 26-36/37/39-43-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C=CC[Si]1(N(C2CCCCC2N1CC3=CC=C(C=C3)Br)CC4=CC=C(C=C4)Br)Cl
Isomeric SMILES:C=CC[Si]1(N([C@@H]2CCCC[C@H]2N1CC3=CC=C(C=C3)Br)CC4=CC=C(C=C4)Br)Cl
Uses Leighton′s Strained Silacycles: Powerful Enantioselective Allylation ReagentsEnantioselective allylation of aldehydes

Technology Process of (1R,2R)-[1,2-Cyclohexanediamino-N,N'-bis(4-bromobenzyl)allylchlorosilane

There total 2 articles about (1R,2R)-[1,2-Cyclohexanediamino-N,N'-bis(4-bromobenzyl)allylchlorosilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 107-37-9
allyltrichlorosilane

: 546084-44-0
(1R,2R)-N,N'-di(4'-bromobenzyl)-1,2-diaminocyclohexane

: 546084-25-7
(R,R)-1,3-bis[(4-bromophenyl)methyl]-2-chlorooctahydro-2-allyl-1H-1,3,2-benzodiazasilole

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 - 20 ℃;
DOI:10.1002/anie.200390252

Reference yield:

: (1R,2R)-(+)-1,2-diaminocyclohexane L-tartrate

: 1122-91-4
4-bromo-benzaldehyde

: 546084-25-7
(R,R)-1,3-bis[(4-bromophenyl)methyl]-2-chlorooctahydro-2-allyl-1H-1,3,2-benzodiazasilole

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; methanesulfonic acid / ethanol; water; dichloromethane / 17 h / 20 °C / Reflux

1.2: 1.5 h / 0 °C / Inert atmosphere; Reflux

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 16 h / 20 °C / Inert atmosphere

With methanesulfonic acid; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; dichloromethane; water;
DOI:10.1002/anie.201409510

Reference yield: 95.0%

: 1443040-75-2
2-((2S,4S,6S)-6-(((2R,4R,6R)-6-((R)-2-((tert-butyldimethylsilyl)oxy)heptadecyl)-2-phenyl-1,3-dioxan-4-yl)methyl)-2-phenyl-1,3-dioxan-4-yl)acetaldehyde

: 546084-25-7
(R,R)-1,3-bis[(4-bromophenyl)methyl]-2-chlorooctahydro-2-allyl-1H-1,3,2-benzodiazasilole

: 1443040-76-3
(S)-1-((2R,4R,6R)-6-(((2R,4R,6R)-6-((R)-2-((tert-butyldimethylsilyl)oxy)heptadecyl)-2-phenyl-1,3-dioxan-4-yl)methyl)-2-phenyl-1,3-dioxan-4-yl)pent-4-en-2-ol

Guidance literature:: With scandium tris(trifluoromethanesulfonate); In dichloromethane; at -10 ℃; for 12h; diastereoselective reaction; Inert atmosphere;
DOI:10.1055/s-0035-1561607