Benzenesulfonamide, 2-amino-4-methyl- (9CI)

Base Information

• Chemical Name: Benzenesulfonamide, 2-amino-4-methyl- (9CI)
• CAS No.: 609-63-2
• Molecular Formula: C7H10N2O2S
• Molecular Weight: 186.235
• Hs Code.: 2935009090
• Mol file: 609-63-2.mol

Synonyms:Benzenesulfonamide, 2-amino-4-methyl- (9CI)

Chemical Property of Benzenesulfonamide, 2-amino-4-methyl- (9CI)

Chemical Property:

• PSA: 94.56000
• LogP: 2.58690

Purity/Quality:

98%min ^*data from raw suppliers

2-AMINO-4-METHYLBENZENESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenesulfonamide, 2-amino-4-methyl- (9CI)

There total 5 articles about Benzenesulfonamide, 2-amino-4-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

isocyanate de chlorosulfonyle (1189-71-5) + 1-amino-3-methylbenzene (108-44-1) → C8H8N2O3S + 2-amino-4-methylbenzenesulfonamide (609-63-2)

Guidance literature:

isocyanate de chlorosulfonyle; 1-amino-3-methylbenzene; In nitromethane; for 0.0833333h; Cooling with ice;

With aluminum (III) chloride; In nitromethane; for 0.5h; Reflux;

With sulfuric acid; In water; for 6h; Reflux;

DOI:10.1021/acs.jmedchem.8b00250

Reference yield:

3-nitro-toluene-4-sulfonic acid amide (20901-98-8) → 2-amino-4-methylbenzenesulfonamide (609-63-2)

Guidance literature:

With iron; ammonium chloride;

DOI:10.1021/jm00338a008

Reference yield:

2-nitro-p-toluenesulfonyl chloride (54090-41-4) → 2-amino-4-methylbenzenesulfonamide (609-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NH₃ / CHCl₃

2: Fe, aq. AcOH

With ammonium hydroxide; iron; acetic acid; In chloroform;

DOI:10.1111/j.2042-7158.1962.tb11132.x

upstream raw materials:

3-nitro-toluene-4-sulfonic acid amide

2-nitro-p-toluenesulfonyl chloride

4-methyl-2-nitroaniline

isocyanate de chlorosulfonyle

Downstream raw materials:

2-Ethyl-N-(5-methyl-2-sulfamoyl-phenyl)-butyramide

2-bromo-N-(5-methyl-2-sulfamoyl-phenyl)-acetamide

4-(6-Methyl-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-butyric acid

3-(6-Methyl-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-propionic acid

Refernces

• 1、 Cameroni,Ferioli,Bernabei. "Heteropolycyclic systems. I. 2,3-Dihydro-1H-pyrrol(2,1-c) (1,2,4) benzothiadiazine-5,5-dioxide and its derivatives". . p. 574 - 581. Retrieved 2007/10/09.
• 2、 BIERBAUM,TRAVERSO,WHITEHEAD. "HYPOTENSIVE 1,2,4-BENZOTHIADIAZINES.". . p. 272 - 275. Retrieved 2007/10/08.