2-(2-Acetyl-phenyl)-isonicotinic acid

Base Information

• Chemical Name: 2-(2-Acetyl-phenyl)-isonicotinic acid
• CAS No.: 566198-32-1
• Molecular Formula: C₁₃H₉NO₃
• Molecular Weight: 227.219
• Hs Code.: 2933399090
• Mol file: 566198-32-1.mol

Synonyms:2-(2-Acetyl-phenyl)-isonicotinic acid;2-(2-Carboxyphenyl)-iso;2-(2-Methoxycarbonylphenyl)-isonicotinic acid;2-(3-Acetyl-phenyl)-isonicotinic acid;2-(3-Methoxycarbonylphenyl)-isonicotinic acid;2-(4-Acetyl-phenyl)-isonicotinic acid;2-(4-Methanesulfonylphenyl)-isonicotinic acid;2-(4-Methoxycarbonylphenyl)-isonicotinic acid

Chemical Property of 2-(2-Acetyl-phenyl)-isonicotinic acid

Chemical Property:

• Melting Point: 278～280℃
• PSA: 67.26000
• LogP: 2.64940

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Formylphenyl)isonicotinic acid >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-Acetyl-phenyl)-isonicotinic acid

There total 2 articles about 2-(2-Acetyl-phenyl)-isonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-formylphenylboronic acid, (87199-17-5) + 2-bromoisonicotinic acid (66572-56-3) → 2-(4-formylphenyl)-isonicotinic acid (566198-32-1)

Guidance literature:

2-bromoisonicotinic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane;

4-formylphenylboronic acid,; With sodium carbonate; for 48h; Heating;

Reference yield:

2-Bromo-4-picoline (4926-28-7) → 2-(4-formylphenyl)-isonicotinic acid (566198-32-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aq. KMnO₄ / Heating

2.1: [Pd(PPh₃)4] / 1,2-dimethoxy-ethane

2.2: 93 percent / aq. Na₂CO₃ / 48 h / Heating

With potassium permanganate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; 2.2: Suzuki-Miyaura coupling reaction;

upstream raw materials:

4-formylphenylboronic acid,

2-bromoisonicotinic acid

2-Bromo-4-picoline