1-(2-methoxyethyl)-1H-pyrrole-2-carbaldehyde

Base Information

• Chemical Name: 1-(2-methoxyethyl)-1H-pyrrole-2-carbaldehyde
• CAS No.: 573720-38-4
• Molecular Formula: C8H11NO2
• Molecular Weight: 153.17844
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID10589891
• Wikidata: Q82483527
• Mol file: 573720-38-4.mol

Synonyms:1-(2-methoxyethyl)-1H-pyrrole-2-carbaldehyde;573720-38-4;1-(2-METHOXYETHYL)PYRROLE-2-CARBALDEHYDE;SCHEMBL3996666;1H-Pyrrole-2-carboxaldehyde, 1-(2-methoxyethyl)- (9CI);DTXSID10589891;MYCMSSGQDMWPFX-UHFFFAOYSA-N;BBL031363;MFCD09674980;STK803286;N-methoxyethylpyrrole-2-carboxaldehyde;AKOS000113671;SB62420;VS-10449;DB-258714;CS-0071804;EN300-265801;F2167-2343

Chemical Property of 1-(2-methoxyethyl)-1H-pyrrole-2-carbaldehyde

Chemical Property:

• Vapor Pressure: 0.019mmHg at 25°C
• Refractive Index: 1.497
• Boiling Point: 252.598°C at 760 mmHg
• PKA: -7.39±0.70(Predicted)
• Flash Point: 106.568°C
• PSA: 31.23000
• Density: 1.046g/cm³
• LogP: 0.94700
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 153.078978594
• Heavy Atom Count: 11
• Complexity: 127

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-(2-methoxyethyl)-1H-pyrrole-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCN1C=CC=C1C=O

Technology Process of 1-(2-methoxyethyl)-1H-pyrrole-2-carbaldehyde

There total 2 articles about 1-(2-methoxyethyl)-1H-pyrrole-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-pyrrole aldehyde (1003-29-8,254729-95-8) + 2-Bromoethyl ethyl ether (592-55-2) → 1-(2-Methoxyethyl)-1H-pyrrole-2-carbaldehyde (573720-38-4)

Guidance literature:

2-pyrrole aldehyde; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1.5h;

2-Bromoethyl ethyl ether; In DMF (N,N-dimethyl-formamide); at 0 - 50 ℃; for 2.75h;

With ammonium chloride; In DMF (N,N-dimethyl-formamide); water; at 20 ℃;

Reference yield:

2-pyrrole aldehyde (1003-29-8,254729-95-8) + 2-Bromoethyl methyl ether (6482-24-2) → 1-(2-Methoxyethyl)-1H-pyrrole-2-carbaldehyde (573720-38-4)

Guidance literature:

2-pyrrole aldehyde; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.5h;

2-Bromoethyl methyl ether; In DMF (N,N-dimethyl-formamide); at 20 ℃;

Reference yield:

1-(2-Methoxyethyl)-1H-pyrrole-2-carbaldehyde (573720-38-4) + N-(4-bromophenyl)-N-methyl-benzenesulfonamide (72385-31-0) → N-(4-{1-hydroxy-1-[1-(2-methoxyethyl)-1H-pyrrol-2-yl]-methyl}-phenyl)-N-methyl-benzenesulfonamide (573720-32-8)

Guidance literature:

N-(4-bromophenyl)-N-methyl-benzenesulfonamide; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.25h;

1-(2-Methoxyethyl)-1H-pyrrole-2-carbaldehyde; In tetrahydrofuran; pentane; at -78 - -30 ℃; for 4h;

With ammonium chloride; In tetrahydrofuran; water; pentane;

upstream raw materials:

2-pyrrole aldehyde

2-Bromoethyl ethyl ether

2-Bromoethyl methyl ether

Downstream raw materials:

N-(4-{1-hydroxy-1-[1-(2-methoxyethyl)-1H-pyrrol-2-yl]-methyl}-phenyl)-N-methyl-benzenesulfonamide