2H-Benzimidazol-2-one,1-acetyl-1,3-dihydro-(9CI)

Base Information

• Chemical Name: 2H-Benzimidazol-2-one,1-acetyl-1,3-dihydro-(9CI)
• CAS No.: 14394-91-3
• Molecular Formula: C9H8 N2 O2
• Molecular Weight: 176.175
• Hs Code.: 2933990090
• Mol file: 14394-91-3.mol

Synonyms:2-Benzimidazolinone,1-acetyl- (6CI,7CI,8CI); 1-Acetyl-2-benzimidazolinone

Chemical Property of 2H-Benzimidazol-2-one,1-acetyl-1,3-dihydro-(9CI)

Chemical Property:

• PSA: 55.12000
• LogP: 1.40200

Purity/Quality:

98%min ^*data from raw suppliers

1-Acetyl-1H-benzimidazol-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Benzimidazol-2-one,1-acetyl-1,3-dihydro-(9CI)

There total 10 articles about 2H-Benzimidazol-2-one,1-acetyl-1,3-dihydro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,3-diacetyl-1,3-dihydro-benzoimidazol-2-one (2735-73-1) + benzylamine (100-46-9) → N-(phenylmethyl)acetamide (588-46-5) + 1-acetyl-1,3-dihydro-2H-benzoimidazol-2-one (14394-91-3)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 0.416667h;

DOI:10.3987/com-99-8779

Reference yield: 77.0%

1-acetyl-3-(prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one (100142-54-9) → 1-acetyl-1,3-dihydro-2H-benzoimidazol-2-one (14394-91-3)

Guidance literature:

With sulfuric acid; In ethanol; water; at 20 ℃; for 30h;

DOI:10.1007/PL00010188

Reference yield: 41.0%

1,3-dihydro-2H-benzimidazol-2-one (615-16-7) + acetyl chloride (75-36-5) → 1-acetyl-1,3-dihydro-2H-benzoimidazol-2-one (14394-91-3)

Guidance literature:

1,3-dihydro-2H-benzimidazol-2-one; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; for 0.0833333h; Inert atmosphere;

acetyl chloride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; for 0.5h; Inert atmosphere;

DOI:10.1021/jacs.1c07060

upstream raw materials:

benzoimidazole

lead(IV) tetraacetate

1-acetyl-3-(prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one

1,3-diacetyl-1,3-dihydro-benzoimidazol-2-one

Downstream raw materials:

1,3-dihydro-2H-benzimidazol-2-one

N⁵-((R)-3-(acetylthio)-1-((carboxymethyl)amino)-1-oxopropan-2-yl)-L-glutamine