2735-73-1

Basic information

• Product Name: 2H-Benzimidazol-2-one, 1,3-diacetyl-1,3-dihydro-
• CAS NO: 2735-73-1
• Molecular Formula: C11H10N2O3
• Molecular Weight: 218.212
• Mol File: 2735-73-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2H-Benzimidazol-2-one, 1,3-diacetyl-1,3-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Benzimidazol-2-one, 1,3-diacetyl-1,3-dihydro-(2735-73-1)
• EPA Substance Registry System: 2H-Benzimidazol-2-one, 1,3-diacetyl-1,3-dihydro-(2735-73-1)

Safety Data

• Hazardous Substances Data: 2735-73-1(Hazardous Substances Data)

Usage

Structural Description

A derivative of benzimidazole with two acetyl groups attached to the nitrogen atom.

Applications

Synthesis: Used in the synthesis of various pharmaceuticals.
Medicinal Chemistry: Potential applications in medicinal chemistry for drug development.

Biological Activity

May exhibit biological activity.

Potential Uses

Drug Development: Valuable building block for the development of new drugs.
Agrochemicals: Potential application in the development of agrochemicals.

Handling and Safety

Importance of Care: It is important to handle this compound with care.
Safety Protocols: Proper safety protocols should be followed due to its potential hazards.

Upstream product

• 615-16-7 1,3-dihydro-2H-benzimidazol-2-one 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 615-16-7 1H-benzimidazol-2-ol 
• 51-17-2 benzoimidazole 
• 18916-43-3 Benzimidazol-N-oxid 

Downstream Products

• 13889-98-0 N-acetylpiperidine 
• 2466-76-4 N-Acetylimidazole 
• 1016-47-3 N-Acetyltryptamine 
• 14394-91-3 1-acetyl-1,3-dihydro-2H-benzoimidazol-2-one 
• 1224708-45-5 1-(4-(4-amino-3-methoxyphenyl)piperidin-1-yl)ethan-1-one 
• 43135-91-7 1,3-benzimidazol-2-one 
• 38674-90-7 4-Acetamido-N-phenylaniline 
• 588-46-5 N-(phenylmethyl)acetamide 
• 579-10-2 N-acetyl-N-methylaniline 
• 103-84-4 Acetanilid 
• 762-84-5 N-tert-butylacetamide 
• 146981-00-2 N-acetyl-N'-phenylethylenediamine 
• 6291-96-9 N-[2-(2-hydroxy-ethylamino)-ethyl]-acetamide 
• 99362-10-4 N-(p-aminobenzyl)acetamide 

Relevant articles and documents

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Inhibitors of the salicylate synthase (Mbti) from Mycobacterium tuberculosis discovered by high-throughput screening

A simple steady-state kinetic high-throughput assay was developed for the salicylate synthase MbtI from Mycobacterium tuberculosis, which catalyzes the first committed step of mycobactin biosynthesis. The mycobactins are small-molecule iron chelators produced by M. tuberculosis, and their biosynthesis has been identified as a promising target for the development of new antitubercular agents. The assay was miniaturized to a 384-well plate format and high-throughput screening was performed at the National Screening Laboratory for the Regional Centers of Excellence in Biodefense and Emerging Infectious Diseases (NSRB). Three classes of compounds were identified comprising the benzisothiazolones (class I), diarylsulfones (class II), and benzimidazole-2-thiones (class III). Each of these compound series was further pursued to investigate their biochemical mechanism and structure-activity relationships. Benzimidazole-2-thione 4 emerged as the most promising inhibitor owing to its potent reversible inhibition.

α-amidoalkylation reactions and oxidation of adducts of benzimidazoles and acyl chlorides

Adducts 4 of benzimidazoles and acyl chlorides were successfully used as electrophilic reagents in an intermolecular α-amidoalkylation reaction toward ketones for synthesis of 2-(2-oxoalkyl)-1,3-diacyl-2,3- dihydrobenzimidazoles 6 and oxidized with KMnO4 to 1,3-diacyl-2,3- dihydrobenzimidazol-2-ones 7.