4-HYDROXY-1-(TOLUENE-4-SULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: 4-HYDROXY-1-(TOLUENE-4-SULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID
• CAS No.: 16257-64-0
• Molecular Formula: C12H15 N O5 S
• Molecular Weight: 285.321
• Mol file: 16257-64-0.mol

Synonyms:TIMTEC-BB SBB012252;AKOS 90624;4-HYDROXY-1-(TOLUENE-4-SULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID;4-HYDROXY-1-[(4-METHYLPHENYL)SULFONYL]-2-PYRROLIDINECARBOXYLIC ACID

Chemical Property of 4-HYDROXY-1-(TOLUENE-4-SULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 9.63E-12mmHg at 25°C
• Melting Point: 157-159°C
• Refractive Index: 1.627
• Boiling Point: 522.5°C at 760 mmHg
• Flash Point: 269.8°C
• PSA: 103.29000
• Density: 1.481g/cm³
• LogP: 1.22220

Purity/Quality:

98%min ^*data from raw suppliers

4-Hydroxy-1-(toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid 95+% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXY-1-(TOLUENE-4-SULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID

There total 2 articles about 4-HYDROXY-1-(TOLUENE-4-SULFONYL)-PYRROLIDINE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.86%

p-toluenesulfonyl chloride (98-59-9) + hydroxy L-proline (618-27-9,30724-02-8) → 4-hydroxy-1-tosylpyrrolidine-2-carboxylic acid (16257-64-0)

Guidance literature:

With sodium carbonate; In water; for 4h;

DOI:10.1371/journal.pone.0191234

Reference yield:

→ 4-hydroxy-1-tosylpyrrolidine-2-carboxylic acid (16257-64-0)

Guidance literature:

allo-4-Hydroxy-prolin, p-Toluolsulfonylchlorid, wss. Alkalihydroxid (Raumtemp.);

DOI:10.1021/ja01075a036

Reference yield:

3-aminoquinoline (580-17-6) + 4-hydroxy-1-tosylpyrrolidine-2-carboxylic acid (16257-64-0) → 4-hydroxy-1-(4-methylbenzenesulfonyl)-N-(quinolin-3-yl)pyrrolidine-2-carboxamide

Guidance literature:

With boric acid; In toluene; Dean-Stark; Reflux; Green chemistry;

DOI:10.1371/journal.pone.0191234

upstream raw materials:

p-toluenesulfonyl chloride

hydroxy L-proline

Refernces