H-ALA-ARG-OH

Base Information

• Chemical Name: H-ALA-ARG-OH
• CAS No.: 16709-12-9
• Molecular Formula: C₉H₁₉N₅O₃
• Molecular Weight: 245.282
• Mol file: 16709-12-9.mol

Synonyms:Arginine,N2-L-alanyl- (7CI); Arginine, N2-L-alanyl-, L- (8CI); Arginine, N2-alanyl-(6CI); L-Arginine, N2-L-alanyl-; 1687: PN: WO2007124090 PAGE: 83 claimedprotein; 19: PN: WO03052099 PAGE: 84 claimed protein; 3: PN: WO0174855 SEQID:14 unclaimed protein; 55: PN: WO2007105565 SEQID: 55 unclaimed protein; 70: PN:US20070066537 PAGE: 17 claimed protein; 74: PN: EP2161028 PAGE: 10 claimed protein;L-Alanyl-L-arginine; N-L-Alanyl-L-arginine; N2-Alanylarginine

Chemical Property of H-ALA-ARG-OH

Chemical Property:

• PKA: 3.13±0.10(Predicted)
• PSA: 157.81000
• Density: 1.45±0.1 g/cm3(Predicted)
• LogP: 0.89780
• Storage Temp.: -15°C

Purity/Quality:

98%Min ^*data from raw suppliers

H-Ala-Arg-OH,99% 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-ALA-ARG-OH

There total 9 articles about H-ALA-ARG-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.7%

Boc-Ala-Arg (497222-34-1) → L-alanine-L-arginine (16709-12-9,55057-56-2,108018-89-9,121394-70-5)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 1h;

DOI:10.1002/cbic.201000759

Reference yield:

Ala-Arg-2-naphthylamide (90836-22-9) → L-alanine-L-arginine (16709-12-9,55057-56-2,108018-89-9,121394-70-5) + naphthalen-2-ylamine (91-59-8)

Guidance literature:

With water; at 37 ℃; for 1h; buffer: Tris (pH: 8.0); dipeptidyl aminopeptidase III (Saccharomyces cerevisiae);

DOI:10.1248/cpb.38.246

Reference yield:

Ala-Arg-AMC (263843-56-7) → L-alanine-L-arginine (16709-12-9,55057-56-2,108018-89-9,121394-70-5)

Guidance literature:

With ethylenediaminetetraacetic acid; dipeptydyl-peptidase DPP₃; sodium phosphate; sodium chloride; In water; at 37 ℃; for 0.5h; pH=7.0; Catalytic behavior; Enzymatic reaction;

DOI:10.1074/jbc.M113.527333

upstream raw materials:

(S)-2-((S)-2-benzyloxycarbonylaminopropanoylamino)-5-nitroguanidinopentanoic acid

Ala-Arg-2-naphthylamide

N-Cbz-alanyl-arginine

L-arginine

Downstream raw materials:

Cum-Phe-Ala-Arg-OH

L-alanin

L-arginine

Refernces

• 1、 Hellwig, Michael,Geissler, Stefanie,Matthes, Rene,Peto, Anett,Silow, Christoph,Brandsch, Matthias,Henle, Thomas. "Transport of Free and Peptide-Bound Glycated Amino Acids: Synthesis, Transepithelial Flux at Caco-2 Cell Monolayers, and Interaction with Apical Membrane Transport Proteins". experimental part. p. 1270 - 1279. Retrieved 2012/04/04.
• 2、 Watanabe,Kumagai,Fujimoto. "Presence of a dipeptidyl aminopeptidase III in Saccharomyces cerevisiae". . p. 246 - 248. Retrieved 2007/10/02.