(S)-2-((S)-2-benzyloxycarbonylaminopropanoylamino)-5-nitroguanidinopentanoic acid

Base Information

• Chemical Name: (S)-2-((S)-2-benzyloxycarbonylaminopropanoylamino)-5-nitroguanidinopentanoic acid
• CAS No.: 13126-00-6
• Molecular Formula: C₁₇H₂₄N₆O₇
• Molecular Weight: 424.414
• Mol file: 13126-00-6.mol

Synonyms:(S)-2-((S)-2-benzyloxycarbonylaminopropanoylamino)-5-nitroguanidinopentanoic acid

Chemical Property of (S)-2-((S)-2-benzyloxycarbonylaminopropanoylamino)-5-nitroguanidinopentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((S)-2-benzyloxycarbonylaminopropanoylamino)-5-nitroguanidinopentanoic acid

There total 7 articles about (S)-2-((S)-2-benzyloxycarbonylaminopropanoylamino)-5-nitroguanidinopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

Nω-nitro-L-arginine (2149-70-4,66036-77-9,137433-32-0) + benzyl N-[(1S)-2-(1H-1,2,3-benzotriazol-1-yl)-1-methyl-2-oxoethyl]carbamate (820239-42-7) → (S)-2-((S)-2-benzyloxycarbonylaminopropanoylamino)-5-nitroguanidinopentanoic acid (13126-00-6)

Guidance literature:

With triethylamine; In water; acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1021/jo800805w

Reference yield:

N-Cbz-Ala (1142-20-7) → Nα-(N-benzyloxycarbonyl-L-alanyl)-Nω-nitro-L-arginine (13126-00-6)

Guidance literature:

With 1,4-dioxane; tributyl-amine; chloroformic acid ethyl ester; anschliessend Behandeln mit N^ω-Nitro-L-arginin-methylester in Dioxan und Behandeln des Reaktionsprodukts mit wss. NaOH;

DOI:10.1021/ja01582a065

Reference yield:

C18H26N6O7 (66345-00-4) → Nα-(N-benzyloxycarbonyl-L-alanyl)-Nω-nitro-L-arginine (13126-00-6)

Guidance literature:

With sodium hydroxide; In acetone;

upstream raw materials:

N-Cbz-Ala

C₁₈H₂₆N₆O₇

L-NAME

N-nitro-L-arginine

Downstream raw materials:

L-alanine-L-arginine