2,3-Dihydrobenzo[b]furan-7-ylamine

Base Information

• Chemical Name: 2,3-Dihydrobenzo[b]furan-7-ylamine
• CAS No.: 13414-56-7
• Molecular Formula: C8H9NO
• Molecular Weight: 135.166
• Hs Code.: 2932999099
• European Community (EC) Number: 691-234-8
• DSSTox Substance ID: DTXSID10510307
• Wikidata: Q82368500
• Mol file: 13414-56-7.mol

Synonyms:13414-56-7;2,3-Dihydrobenzofuran-7-amine;2,3-dihydrobenzo[b]furan-7-ylamine;2,3-dihydro-1-benzofuran-7-amine;7-amino-2,3-dihydrobenzofuran;2,3-dihydro-benzofuran-7-ylamine;MFCD11109313;(2,3-Dihydrobenzofuran-7-yl)amine;2,3-Dihydro-7-benzofuranamine;2,3-Dihydrobenzo(b)furan-7-ylamine;7-Benzofuranamine, 2,3-dihydro-;2,3-dihydro-7-benzofuranamine;SCHEMBL569841;DTXSID10510307;UHHZGSLXPQGPJL-UHFFFAOYSA-N;AMY24235;BCP14902;CS-B1184;AKOS006309802;SB32917;AS-55162;SY033410;2,3-Dihydrobenzo[b]furan-7-ylamine,97%;FT-0758533;EN300-314309;Y10505;2,3-Dihydrobenzo[b]furan-7-ylamine, AldrichCPR;A887954;W-205433;W-205434

Chemical Property of 2,3-Dihydrobenzo[b]furan-7-ylamine

Chemical Property:

• Boiling Point: 271.063 °C at 760 mmHg
• PKA: 4.66±0.20(Predicted)
• Flash Point: 136.589 °C
• PSA: 35.25000
• Density: 1.208 g/cm³
• LogP: 1.78490
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 135.068413911
• Heavy Atom Count: 10
• Complexity: 126

Purity/Quality:

99%+, ^*data from raw suppliers

2,3-Dihydrobenzofuran-7-Amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC2=C1C=CC=C2N

Technology Process of 2,3-Dihydrobenzo[b]furan-7-ylamine

There total 5 articles about 2,3-Dihydrobenzo[b]furan-7-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.6%

2.3-dihydrobenzofuran (496-16-2) → 2,3-dihydro-1-benzofuran-5-amine (42933-43-7) + 2,3-dihydrobenzo[b]furan-7-ylamine (13414-56-7)

Guidance literature:

With O-(4-nitrobenzoyl)hydroxylammonium trifluoromethanesulfonate; iron(II) bromide; silver(I) triflimide; In 2,2,2-trifluoroethanol; water; at 30 ℃; for 2h;

DOI:10.1002/chem.201605476

Reference yield:

2,3-dihydro-benzofuran-7-carbonyl azide → 2,3-dihydrobenzo[b]furan-7-ylamine (13414-56-7)

Guidance literature:

With sodium hydroxide; In methanol; Heating;

DOI:10.1016/j.bmcl.2005.04.077

Reference yield:

2.3-dihydrobenzofuran (496-16-2) → 2,3-dihydrobenzo[b]furan-7-ylamine (13414-56-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / BuLi; TMEDA / heptane / -70 - 20 °C

2: NaN₃; TFA; TFAA / 20 °C

3: NaOH / methanol / Heating

With sodium hydroxide; n-butyllithium; sodium azide; N,N,N,N,-tetramethylethylenediamine; trifluoroacetic acid; trifluoroacetic anhydride; In methanol; n-heptane;

DOI:10.1016/j.bmcl.2005.04.077

upstream raw materials:

2.3-dihydrobenzofuran

2,3-dihydrobenzofuran-7-carboxylic acid

Refernces

• 1、 Liu, Jianzhong,Wu, Kai,Shen, Tao,Liang, Yujie,Zou, Miancheng,Zhu, Yuchao,Li, Xinwei,Li, Xinyao,Jiao, Ning. "Fe-Catalyzed Amination of (Hetero)Arenes with a Redox-Active Aminating Reagent under Mild Conditions". supporting information. p. 563 - 567. Retrieved 2017/01/18.
• 2、 -. "Tricyclic furo-quinazolinones". . . Retrieved 2008/06/13.