2-Fluoro-p-Xylene

Base Information

• Chemical Name: 2-Fluoro-p-Xylene
• CAS No.: 696-01-5
• Molecular Formula: C8H9 F
• Molecular Weight: 124.158
• Hs Code.: 2903999090
• Mol file: 696-01-5.mol

Synonyms:p-Xylene,2-fluoro- (6CI,7CI,8CI); 1,4-Dimethyl-2-fluorobenzene;2-Fluoro-1,4-dimethylbenzene; 2-Fluoro-p-xylene

Chemical Property of 2-Fluoro-p-Xylene

Chemical Property:

• Melting Point: -6℃
• Boiling Point: 144.7℃
• Flash Point: 30.9℃
• PSA: 0.00000
• Density: 0.983
• LogP: 2.44250
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

2-Fluoro-p-xylene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoro-p-Xylene

There total 10 articles about 2-Fluoro-p-Xylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

para-xylene (106-42-3) → α-fluoro-p-xylene (459-50-7) + 2-fluoro-1,4-dimethylbenzene (696-01-5)

Guidance literature:

With caesium fluoroxysulphate; In acetonitrile; at 35 - 40 ℃; for 1h; Yields of byproduct given;

DOI:10.1021/jo00026a032

Reference yield: 65.5%

2,5-Dimethylaniline (95-78-3) → 2-fluoro-1,4-dimethylbenzene (696-01-5)

Guidance literature:

With sodium nitrite; In Et₃N-3HF;

Reference yield:

para-xylene (106-42-3) → p-fluorotoluene (352-32-9) + methyl radical (2229-07-4) + 4-methylbenzyl radical (2348-52-9) + 2-fluoro-1,4-dimethylbenzene (696-01-5)

Guidance literature:

With fluorine; at 296 ℃; under 1.5 Torr; Rate constant; Product distribution; Thermodynamic data; Irradiation; different initial F atom concentration;

upstream raw materials:

2,5-Dimethylaniline

para-xylene

2,2,2-trifluoroethanol

mononitro-p-xylene

Downstream raw materials:

4-(chloromethyl)-2-fluoro-1-methylbenzene

2-fluoro-4-methylbenzyl chloride

2-fluoro-1,4-dichloromethylbenzene

1-(bromomethyl)-2-fluoro-4-methylbenzene

Refernces

• 1、 Laali, Kenneth K.,Borodkin, Gennady I.. "First application of ionic liquids in electrophilic fluorination of arenes; Selectfluor (F-TEDA-BF4) for "green" fluorination". . p. 953 - 957. Retrieved 2007/10/03.
• 2、 Canning, Peter S. J.,Maskill, Howard,McCrudden, Katharine,Sexton, Brian. "A product analytical study of the thermal and photolytic decomposition of some arenediazonium salts in solution". . p. 789 - 800. Retrieved 2007/10/03.