Pyrrole-2-glyoxyloyl chloride, 1-methyl- (8CI)

Base Information

• Chemical Name: Pyrrole-2-glyoxyloyl chloride, 1-methyl- (8CI)
• CAS No.: 13999-72-9
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.583
• Mol file: 13999-72-9.mol

Synonyms:Pyrrole-2-glyoxyloylchloride, 1-methyl- (8CI)

Chemical Property of Pyrrole-2-glyoxyloyl chloride, 1-methyl- (8CI)

Chemical Property:

• PSA: 39.07000
• LogP: 0.97320

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrrole-2-glyoxyloyl chloride, 1-methyl- (8CI)

There total 1 articles about Pyrrole-2-glyoxyloyl chloride, 1-methyl- (8CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Methylpyrrole (96-54-8) + oxalyl dichloride (79-37-8) → C7H6ClNO2 (13999-72-9)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.200900119

Reference yield:

C7H6ClNO2 (13999-72-9) + tributylstannylethynylbenzene (3757-88-8) → 1-(1-methyl-1H-pyrrol-2-yl)-3-phenylprop-2-yn-1-one (144912-21-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In tetrahydrofuran; at 60 ℃; for 1h; Inert atmosphere;

DOI:10.1055/s-0029-1218802

Reference yield:

C7H6ClNO2 (13999-72-9) + phenylacetylene (536-74-3) → 1-(1-methyl-1H-pyrrol-2-yl)-4-phenylbut-3-yne-1,2-dione (1289675-79-1)

Guidance literature:

With copper(l) iodide; triethylamine; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/anie.201007194

upstream raw materials:

N-Methylpyrrole

oxalyl dichloride

Downstream raw materials:

1-(1-methyl-1H-pyrrol-2-yl)-3-phenylprop-2-yn-1-one

1-(1-methyl-1H-pyrrol-2-yl)-4-phenylbut-3-yne-1,2-dione

Refernces

• 1、 Gers, Charlotte F.,Nordmann, Jan,Kumru, Ceyda,Frank, Walter,Müller, Thomas J. J.. "Solvatochromic fluorescent 2-substituted 3-ethynyl quinoxalines: Four-component synthesis, photophysical properties, and electronic structure". . p. 3296 - 3310. Retrieved 2014/05/06.
• 2、 Tasch, Boris O. A.,Merkul, Eugen,Frank, Walter,Mueller, Thomas J.J.. "New three-component glyoxylation-decarbonylative stille coupling sequence to Acyl heterocycles under mild conditions". experimental part. p. 2139 - 2146. Retrieved 2010/09/04.