CIS-1,2-DIMETHYL-CYCLOPROPANEDICARBOXYLIC ACID

Base Information

• Chemical Name: CIS-1,2-DIMETHYL-CYCLOPROPANEDICARBOXYLIC ACID
• CAS No.: 699-49-0
• Molecular Formula: C₇H₁₀O₄
• Molecular Weight: 158.154
• Hs Code.: 2917209090
• Mol file: 699-49-0.mol

Synonyms:CIS-1,2-DIMETHYL-CYCLOPROPANEDICARBOXYLIC ACID

Chemical Property of CIS-1,2-DIMETHYL-CYCLOPROPANEDICARBOXYLIC ACID

Chemical Property:

• PSA: 63.60000
• LogP: 0.27020

Purity/Quality:

98% ^*data from raw suppliers

CIS-1,2-DIMETHYL-CYCLOPROPANEDICARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CIS-1,2-DIMETHYL-CYCLOPROPANEDICARBOXYLIC ACID

There total 10 articles about CIS-1,2-DIMETHYL-CYCLOPROPANEDICARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(+/-)-(1R,2S)-diethyl 1,2-dimethylcyclopropane-1,2-dicarboxylate (714-79-4) → cis-1,2-Dimethyl-1,2-cyclopropanedicarboxylic acid (699-49-0)

Guidance literature:

With water; potassium hydroxide; In tetrahydrofuran; for 24h; Heating;

DOI:10.1080/14756366.2016.1218486

Reference yield:

2-chloro-propionic acid methyl ester (17639-93-9) + methyl methacrylate (97-63-2,9003-42-3) → cis-1,2-Dimethyl-1,2-cyclopropanedicarboxylic acid (699-49-0)

Guidance literature:

With sodium hydride; Hydrolysieren des Reaktionsprodukts;

DOI:10.1021/ja01557a029

Reference yield:

1,2-Dimethyl-r-1,c-2-cyclopropandicarbonsaeure-dimethylester (6914-70-1) → cis-1,2-Dimethyl-1,2-cyclopropanedicarboxylic acid (699-49-0)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

2-chloro-propionic acid methyl ester

methyl methacrylate

2-chloro-propanoic acid, ethyl ester

1,2-Dimethyl-r-1,c-2-cyclopropandicarbonsaeure-dimethylester

Downstream raw materials:

1,2-dimethyl-cyclopropane-1r,2c-dicarboxylic acid anhydride

c-2-Chlorformyl-1,2-dimethyl-r-1-cyclopropancarbonsaeure

(1R,2S)-1,2-Dimethyl-cyclopropane-1,2-dicarbonyl dichloride

cis-1,2-Dimethyl-2-acetyl-cyclopropan-carbonsaeure-⁽¹⁾-methylester

Refernces

• 1、 Beato, Claudia,Pecchini, Chiara,Cocconcelli, Chiara,Campanini, Barbara,Marchetti, Marialaura,Pieroni, Marco,Mozzarelli, Andrea,Costantino, Gabriele. "Cyclopropane derivatives as potential human serine racemase inhibitors: Unveiling novel insights into a difficult target". . p. 645 - 652. Retrieved 2016/05/09.
• 2、 Saal, Wolfgang von der,Reinhardt, Robert,Seidenspinner, Hubert-Matthias,Stawitz, Josef,Quast, Helmut. "Cyclopropanediamines, 3. - Pure Diastereomers of 1,2-Cyclopropanedicarboxylic Acids and Derivatives". . p. 703 - 712. Retrieved 2007/10/02.