Z-LEU-PHE-NH2

Base Information

• Chemical Name: Z-LEU-PHE-NH2
• CAS No.: 13171-96-5
• Molecular Formula: C23H29 N3 O4
• Molecular Weight: 411.501
• Mol file: 13171-96-5.mol

Synonyms:Carbamic acid,[1-[(a-carbamoylphenethyl)carbamoyl]-3-methylbutyl]-,benzyl ester (7CI); Carbamic acid, [1-[(a-carbamoylphenethyl)carbamoyl]-3-methylbutyl]-, benzylester, stereoisomer (8CI); (N-Benzyloxycarbonyl)-L-leucyl-L-phenylalanamide

Chemical Property of Z-LEU-PHE-NH2

Chemical Property:

• Boiling Point: 686.4±55.0 °C(Predicted)
• PKA: 11.14±0.46(Predicted)
• PSA: 118.49000
• Density: 1.170±0.06 g/cm3(Predicted)
• LogP: 4.73470
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

Z-Leu-Phe-NH2 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-LEU-PHE-NH2

There total 7 articles about Z-LEU-PHE-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-benzyloxycarbonyl-L-leucine methyl ester (51021-87-5) + (S)-2-amino-3-phenylpropionamide hydrochloride (65864-22-4) → Cbz-Leu-Phe-NH2 (13171-96-5)

Guidance literature:

With sodium carbonate decahydrate; L-Cysteine; papain; for 2h; Milling; Enzymatic reaction;

DOI:10.1039/c7gc00615b

Reference yield: 82.0%

N-(benzyloxycarbonyl)-L-leucyl-L-phenylalanine methyl ester (10473-38-8,16679-86-0,120342-23-6,4818-00-2) → Cbz-Leu-Phe-NH2 (13171-96-5)

Guidance literature:

With ammonia; In methanol; for 48h; Ambient temperature;

Reference yield: 68.2%

Cbz-Leu-OCH2CONH2 + L-Phenylalanine amide (5241-58-7) → Z-Leu-OH (2018-66-8) + Cbz-Leu-Phe-NH2 (13171-96-5)

Guidance literature:

With phosphate buffer; α-chymotrypsin; In dimethyl sulfoxide; at -24 ℃; for 120h; pH=8.0;

DOI:10.1016/j.tetasy.2005.10.042

upstream raw materials:

ethyl N-benzyloxycarbonyl-L-leucyl-L-phenylalaninate

N-(benzyloxycarbonyl)-L-leucyl-L-phenylalanine methyl ester

N-benzyloxycarbonyl-L-leucyl-L-phenylalanine

L-Phenylalanine amide

Downstream raw materials:

N-benzyloxycarbonyl-L-leucyl-L-phenylalanine

N-(benzyloxycarbonyl)-L-leucyl-L-phenylalanine methyl ester