1H-Indole-1-carboxamide(9CI)

Base Information

• Chemical Name: 1H-Indole-1-carboxamide(9CI)
• CAS No.: 13307-58-9
• Molecular Formula: C9H8N2O
• Molecular Weight: 160.175
• Hs Code.: 2933990090
• Mol file: 13307-58-9.mol

Synonyms:1H-Indole-1-carboxamide(9CI)

Chemical Property of 1H-Indole-1-carboxamide(9CI)

Chemical Property:

• PSA: 49.01000
• LogP: 2.08190

Purity/Quality:

1H-Indole-1-carboxamide 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole-1-carboxamide(9CI)

There total 2 articles about 1H-Indole-1-carboxamide(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

N-methoxy-1H-indole-1-carboxamide (1616115-84-4) + diphenyl acetylene (501-65-5) → indolecarboxamide (13307-58-9) + (Z)-3-(1H-indol-2-yl)-N-methoxy-2,3-diphenylacrylamide

Guidance literature:

With [RhCl₂(p-cymene)]2; sodium acetate; In methanol; at 20 ℃; for 1h; Reagent/catalyst; Solvent; Concentration; Catalytic behavior;

DOI:10.1039/d0ob00508h

Reference yield:

indole (120-72-9) → indolecarboxamide (13307-58-9) + (Z)-3-(1H-indol-2-yl)-N-methoxy-2,3-diphenylacrylamide

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap / acetonitrile / 10 h / 85 °C / Inert atmosphere

1.2: 6 h / 80 °C / Inert atmosphere

2.1: [RhCl₂(p-cymene)]2; sodium acetate / methanol / 1 h / 20 °C

With dmap; [RhCl₂(p-cymene)]2; sodium acetate; In methanol; acetonitrile;

DOI:10.1039/d0ob00508h

Reference yield: 79.0%

indole (120-72-9) + indolecarboxamide (13307-58-9) + 4-methoxy-benzaldehyde (123-11-5) → 3-((1H-indol-3-yl)(4-methoxyphenyl)methyl)-1H-indole-1-carboxamide

Guidance literature:

With silica-potassium hydrogen sulfate; at 25 ℃; for 0.5h; Green chemistry;

DOI:10.1016/j.inoche.2021.108620

upstream raw materials:

N-methoxy-1H-indole-1-carboxamide

diphenyl acetylene

indole

Refernces