(4S)-4-METHYL-L-PROLINE

Base Information

• Chemical Name: (4S)-4-METHYL-L-PROLINE
• CAS No.: 6734-41-4
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.159
• Hs Code.: 2933990090
• Mol file: 6734-41-4.mol

Synonyms:

Chemical Property of (4S)-4-METHYL-L-PROLINE

Chemical Property:

• Vapor Pressure: 0.007mmHg at 25°C
• Boiling Point: 250.244°C at 760 mmHg
• Flash Point: 105.144°C
• PSA: 49.33000
• LogP: 0.39780
• Storage Temp.: 2-8°C

Purity/Quality:

99.3% ^*data from raw suppliers

(2S,4S)-4-Methylpyrrolidine-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4S)-4-METHYL-L-PROLINE

There total 7 articles about (4S)-4-METHYL-L-PROLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

C8H16ClNO2 (77120-56-0) → cis-4-methyl-(S)-proline (6734-41-4) + trans-4-methyl-L-proline (23009-50-9)

Guidance literature:

With sodium hydroxide; sulfuric acid; Yield given. Multistep reaction; 1) 0 deg C, 40 h irradiation (2500-3000 Angstroem); 2) 0 deg C, pH 7-7.4, then 2 h reflux in 0.24N methanolic NaOH; further activation methods;

DOI:10.1016/0040-4020(80)88020-3

Reference yield:

leucinostatin A (82111-44-2) → L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) + (2S,3S)-3-hydroxyleucine (10148-70-6) + cis-4-methyl-(S)-proline (6734-41-4) + 2-Aminoisobutyric acid (62-57-7)

Guidance literature:

With hydrogenchloride; at 110 ℃; for 20h; Further byproducts given;

DOI:10.1039/c39820000094

Reference yield:

leucinostatin A (82111-44-2) → (2S,3S)-3-hydroxyleucine (10148-70-6) + cis-4-methyl-(S)-proline (6734-41-4) + 2-Aminoisobutyric acid (62-57-7) + 3-amino propanoic acid (107-95-9)

Guidance literature:

With hydrogenchloride; at 110 ℃; for 20h; Further byproducts given;

DOI:10.1039/c39820000094

upstream raw materials:

C₈H₁₆ClNO₂

P₁₆₈

leucinostatin A

Refernces

• 1、 Golakoti, Trimurtulu,Yoshida, Wesley Y.,Chaganty, Sreedhara,Moore, Richard E.. "Isolation and structures of nostopeptolides A1, A2 and A3 from the cyanobacterium Nostoc sp. GSV224". . p. 9093 - 9102. Retrieved 2007/10/03.
• 2、 Mori, Yuji,Tsuboi, Makoto,Suzuki, Makoto,Fukushima, Kazutaka,Arai, Tadashi. "Structure of Leucinostatin A, New Peptide Antibiotic from Paecilomyces lilacinus A-267". . p. 94 - 96. Retrieved 2007/10/02.