(S)-Methyl azetidine-2-carboxylate hydrochloride

Base Information

• Chemical Name: (S)-Methyl azetidine-2-carboxylate hydrochloride
• CAS No.: 69684-69-1
• Molecular Formula: C5H10ClNO2
• Molecular Weight: 151.593
• Hs Code.: 2933998090
• European Community (EC) Number: 676-240-0
• DSSTox Substance ID: DTXSID50531753
• Mol file: 69684-69-1.mol

Synonyms:69684-69-1;(S)-Methyl azetidine-2-carboxylate hydrochloride;methyl (2S)-azetidine-2-carboxylate hydrochloride;(s)-azetidine-2-carboxylic acid methyl ester hydrochloride;Methyl L-azetidine-2-carboxylate HCl;Methyl L-azetidine-2-carboxylate hydrochloride;methyl (2S)-azetidine-2-carboxylate;hydrochloride;(S)-METHYL 2-AZETIDINECARBOXYLATE HYDROCHLORIDE;methyl (s)-azetidine-2-carboxylate hydrochloride;(S)-Azetidine-2-carboxylic acid methyl ester, HCl;(S)-Methyl 2-azetidinecarboxylate HCl;MFCD07369973;SCHEMBL708359;DTXSID50531753;FKHBGZKNRAUKEF-WCCKRBBISA-N;AMY38525;AKOS015998978;(S)-methyl azetidine-2-carboxylate HCl;AS-38028;CS-0049286;(S)-Methylazetidine-2-carboxylatehydrochloride;EN300-7392660;(2S)-Methyl azetidine-2-carboxylate hydrochloride;A836608;methyl (S)-(-)-Azetidine-2-carboxylate hydrochloride;Methyl (2S)-azetidine-2-carboxylate hydrochloride (1:1);azetidine-2(S)-carboxylic acid, methyl ester hydrochloride salt;Methyl (2S)-azetidine-2-carboxylate--hydrogen chloride (1/1);51020-00-9

Chemical Property of (S)-Methyl azetidine-2-carboxylate hydrochloride

Chemical Property:

• Vapor Pressure: 0.449mmHg at 25°C
• Boiling Point: 190.9°C at 760 mmHg
• Flash Point: 69.3°C
• PSA: 38.33000
• LogP: 0.65210
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 151.0400063
• Heavy Atom Count: 9
• Complexity: 103

Purity/Quality:

99% ^*data from raw suppliers

(S)-Azetidine-2-carboxylicacidmethylesterHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1CCN1.Cl
• Isomeric SMILES: COC(=O)[C@@H]1CCN1.Cl

Technology Process of (S)-Methyl azetidine-2-carboxylate hydrochloride

There total 1 articles about (S)-Methyl azetidine-2-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

→ 1-(tert-butoxycarbonyl)-2-methylazetidine-2-carboxylic acid (449758-77-4,1198339-37-5) + (S)-Azetidin-2-carbonsaeuremethylester-hydrochlorid (69684-69-1,51020-00-9)

Guidance literature:

Reference yield: 87.0%

dmap (1122-58-3) + di-tert-butyl dicarbonate (24424-99-5) + (S)-Azetidin-2-carbonsaeuremethylester-hydrochlorid (69684-69-1,51020-00-9) → azetidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (255882-72-5)

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield: 64.0%

N-Cbz-Ala (1142-20-7) + (S)-Azetidin-2-carbonsaeuremethylester-hydrochlorid (69684-69-1,51020-00-9) → C16H20N2O5 (1192501-19-1)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/jo901712x

Downstream raw materials:

methyl (S)-1-benzyl-2-azetidinecarboxylate

azetidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

(S)-1-[(R)-5-(4-cyanobenzyl)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-azetidine-2-carboxylic acid methyl ester

(S)-1-[(R)-7-(3,5-dichlorophenyl)-5-methyl-6-oxo-5-(4-pyrimidin-5-yl-benzyl)-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-azetidine-2-carboxylic acid methyl ester

Refernces