4-ETHOXY-2-BUTANONE

Base Information

• Chemical Name: 4-ETHOXY-2-BUTANONE
• CAS No.: 60044-74-8
• Molecular Formula: C6H12O2
• Molecular Weight: 116.16
• Hs Code.: 2914509090
• Mol file: 60044-74-8.mol

Synonyms:4-ETHOXY-2-BUTANONE;4-ETHOXY-2-BUTANONE 90+%;2-Butanone, 4-ethoxy- (6CI,7CI,9CI)

Chemical Property of 4-ETHOXY-2-BUTANONE

Chemical Property:

• Vapor Pressure: 3.72mmHg at 25°C
• Refractive Index: 1.397
• Boiling Point: 153°C
• Flash Point: 39.6°C
• PSA: 26.30000
• Density: 0,92 g/cm3
• LogP: 1.00200

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Ethoxy-2-butanone ^*data from reagent suppliers

Safty Information:

• Statements: 10
• Safety Statements: 16

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ETHOXY-2-BUTANONE

There total 17 articles about 4-ETHOXY-2-BUTANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + methyl vinyl ketone (78-94-4,25038-87-3) → 4-ethoxy-butan-2-one (60044-74-8)

Guidance literature:

With tributylphosphine; at 50 ℃; for 0.000277778h; under 750.06 Torr;

DOI:10.1016/S0040-4039(01)00872-3

Reference yield: 50.9%

1-acetoxybutan-3-one (10150-87-5) → 4-ethoxy-butan-2-one (60044-74-8)

Guidance literature:

With hydrogenchloride; trichlorosilane; at 60 ℃; Irradiation;

DOI:10.1016/0022-328X(89)85276-3

Reference yield:

2,3-dihydro-2H-furan (1191-99-7,75454-45-4) + (Z)-3-Ethoxy-but-2-en-1-ol (881421-26-7,90036-85-4) → 2-ethoxytetrahydrofuran (13436-46-9) + cis-4-(2-ethoxytetrahydrofuran-3-yl)butan-2-one (112698-03-0,112698-10-9) + trans-4-(2-ethoxytetrahydrofuran-3-yl)butan-2-one (112698-03-0,112698-10-9) + 4-ethoxy-butan-2-one (60044-74-8)

Guidance literature:

With boron trifluoride diethyl etherate; In nitromethane; at -20 ℃; for 0.5h; Yield given;

DOI:10.1016/S0040-4039(00)95506-0

upstream raw materials:

3-buten-1-yne

ethanol

methyl vinyl ketone

dimethylcadmium

Downstream raw materials:

methyl vinyl ketone

3-methyl-1-phenyl-4,5-dihydropyrazole

1-Propyloxy-butanon-(3)

4-ethoxy-butan-2-one-(2,4-dinitro-phenylhydrazone)

Refernces

• 1、 Das, Debjit,Pratihar, Sanjay,Roy, Sujit. "Heterobimetallic Pd-Sn catalysis: Michael addition reaction with C-, N-, O-, and S-nucleophiles and in situ diagnostics". . p. 2430 - 2442. Retrieved 2013/04/23.
• 2、 Bernal, Pablo,Tamariz, Joaquín. "Synthesis of novel β-functionalized α-oximinoketones via hetero-Michael addition of alcohols and mercaptans to enones". . p. 2905 - 2909. Retrieved 2007/10/03.