3-AMINO-4-METHOXYBENZENE-METHANAMINE DIHYDROCHLORIDE

Base Information

• Chemical Name: 3-AMINO-4-METHOXYBENZENE-METHANAMINE DIHYDROCHLORIDE
• CAS No.: 60518-02-7
• Molecular Formula: C8H12N2O
• Molecular Weight: 152.196
• Mol file: 60518-02-7.mol

Synonyms:3-AMINO-4-METHOXYBENZENE-METHANAMINE DIHYDROCHLORIDE;Benzenemethanamine, 3-amino-4-methoxy-

Chemical Property of 3-AMINO-4-METHOXYBENZENE-METHANAMINE DIHYDROCHLORIDE

Chemical Property:

Purity/Quality:

99%min ^*data from raw suppliers

5-Aminomethyl-2-methoxy-phenylamine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMINO-4-METHOXYBENZENE-METHANAMINE DIHYDROCHLORIDE

There total 5 articles about 3-AMINO-4-METHOXYBENZENE-METHANAMINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-amino-4-methoxybenzamide (17481-27-5) → 5-(aminomethyl)-2-methoxyaniline (60518-02-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 65 ℃;

DOI:10.1021/acsmedchemlett.9b00365

Reference yield:

4-(4-methoxy-3-nitro-benzyl)-acetamide → 5-(aminomethyl)-2-methoxyaniline (60518-02-7)

Guidance literature:

With hydrogenchloride; tin;

Reference yield:

(E)-4-methoxybenzaldoxime (3717-21-3,3717-22-4,3235-04-9,140461-28-5,140461-29-6) → 5-(aminomethyl)-2-methoxyaniline (60518-02-7)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid; alcohol; sodium amalgam

3: nitric acid

4: tin; hydrochloric acid

With hydrogenchloride; tin; sodium amalgam; ethanol; nitric acid; acetic acid;

upstream raw materials:

3-amino-4-methoxybenzamide

(E)-4-methoxybenzaldoxime

N-(p-methoxybenzyl)acetamide

4-methoxy-benzylamine

Refernces

• 1、 Zhao, Guohua,Bolton, Scott A.,Kwon, Chet,Hartl, Karen S.,Seiler, Steven M.,Slusarchyk, William A.,Sutton, James C.,Bisacchi, Gregory S.. "Synthesis of potent and selective 2-azepanone inhibitors of human tryptase". . p. 309 - 312. Retrieved 2007/10/03.