1-(6-Bromopyridin-2-YL)-N-methylmethanamine

Base Information

• Chemical Name: 1-(6-Bromopyridin-2-YL)-N-methylmethanamine
• CAS No.: 675109-37-2
• Molecular Formula: C7H9BrN2
• Molecular Weight: 201.066
• Hs Code.: 2933399990
• DSSTox Substance ID: DTXSID40594690
• Wikidata: Q82489596
• Mol file: 675109-37-2.mol

Synonyms:675109-37-2;6-BROMO-N-METHYLPYRID-2-YLMETHYLAMINE;1-(6-BROMOPYRIDIN-2-YL)-N-METHYLMETHANAMINE;(6-BROMO-PYRIDIN-2-YLMETHYL)-METHYL-AMINE;[(6-bromopyridin-2-yl)methyl](methyl)amine;SCHEMBL2679367;DTXSID40594690;UXUZAQVJXNKSIZ-UHFFFAOYSA-N;MFCD08690325;(6-Bromopyridin-2-ylmethyl)methylamine;AB48344;DB-073884;C76128;EN300-1910236

Chemical Property of 1-(6-Bromopyridin-2-YL)-N-methylmethanamine

Chemical Property:

• Vapor Pressure: 0.0225mmHg at 25°C
• Refractive Index: 1.556
• Boiling Point: 249.8°C at 760 mmHg
• Flash Point: 104.9°C
• PSA: 24.92000
• Density: 1.431g/cm³
• LogP: 1.95440
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 199.99491
• Heavy Atom Count: 10
• Complexity: 97.6

Purity/Quality:

98%min ^*data from raw suppliers

(6-Bromopyridin-2-ylmethyl)methylamine 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNCC1=NC(=CC=C1)Br

Technology Process of 1-(6-Bromopyridin-2-YL)-N-methylmethanamine

There total 2 articles about 1-(6-Bromopyridin-2-YL)-N-methylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromo-2-pyridinecarbaldehyde (34160-40-2) + methylamine (74-89-5) → 1-(6-bromopyridin-2-yl)-N-methylmethanamine (675109-37-2)

Guidance literature:

In tetrahydrofuran; dichloromethane; at 20 ℃; for 18h;

Reference yield:

→ 1-(6-bromopyridin-2-yl)-N-methylmethanamine (675109-37-2)

Guidance literature:

Reference yield: 27.0%

1-(6-bromopyridin-2-yl)-N-methylmethanamine (675109-37-2) + 4-(((2S,5R)-1-(tert-butoxycarbonyl)-5-((R)-((tert-butyldimethylsilyl)oxy)(phenyl)methyl)pyrrolidin-2-yl)methyl)benzoic acid (1269429-21-1) → tert-butyl (2R,5S)-2-(4-{[(6-bromopyridin-2-yl)methyl](methyl)carbamoyl}benzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-pyrrolidine-1-carboxylate (1269615-54-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

upstream raw materials:

6-bromo-2-pyridinecarbaldehyde

methylamine

Downstream raw materials:

tert-butyl (2R,5S)-2-(4-{[(6-bromopyridin-2-yl)methyl](methyl)carbamoyl}benzyl)-5-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(phenyl)methyl]-pyrrolidine-1-carboxylate

tert-butyl [(6-bromopyridin-2-yl)methyl]methylcarbamate