4-(4-CHLOROBENZYLIDENEAMINO)ANTIPYRINE

Base Information

• Chemical Name: 4-(4-CHLOROBENZYLIDENEAMINO)ANTIPYRINE
• CAS No.: 61098-04-2
• Molecular Formula: C18H16ClN3O
• Molecular Weight: 325.798
• Hs Code.: 2933199090
• Mol file: 61098-04-2.mol

Synonyms:4-(4-CHLOROBENZYLIDENEAMINO)ANTIPYRINE

Chemical Property of 4-(4-CHLOROBENZYLIDENEAMINO)ANTIPYRINE

Chemical Property:

• PSA: 39.29000
• LogP: 3.88840

Purity/Quality:

99%min ^*data from raw suppliers

4-(4-CHLOROBENZYLIDENEAMINO)ANTIPYRINE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-CHLOROBENZYLIDENEAMINO)ANTIPYRINE

There total 4 articles about 4-(4-CHLOROBENZYLIDENEAMINO)ANTIPYRINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one (83-07-8) + 4-chlorobenzaldehyde (104-88-1) → 4-(4-chlorobenzylideneamino)-1,2-dihydro-1,5-dimethyl-2-phenylpyrazol-3-one (61098-04-2)

Guidance literature:

at 20 ℃; for 1h;

Reference yield:

1,5-dimethyl-4-nitroso-2-phenyl-1,2-dihydro-pyrazol-3-one (885-11-0) → 4-(4-chlorobenzylideneamino)-1,2-dihydro-1,5-dimethyl-2-phenylpyrazol-3-one (61098-04-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; zinc / water; ethanol / 0 - 5 °C

2: acetic acid / ethanol / 4 h / Reflux

With acetic acid; zinc; In ethanol; water;

DOI:10.1016/j.bioorg.2018.11.016

Reference yield:

antipyrine (60-80-0) → 4-(4-chlorobenzylideneamino)-1,2-dihydro-1,5-dimethyl-2-phenylpyrazol-3-one (61098-04-2)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; sodium nitrite / water / 0.33 h / 0 - 5 °C

2: acetic acid; zinc / water; ethanol / 0 - 5 °C

3: acetic acid / ethanol / 4 h / Reflux

With acetic acid; zinc; sodium nitrite; In ethanol; water;

DOI:10.1016/j.bioorg.2018.11.016

upstream raw materials:

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one

4-chlorobenzaldehyde

1,5-dimethyl-4-nitroso-2-phenyl-1,2-dihydro-pyrazol-3-one

antipyrine

Downstream raw materials:

C₃₀H₂₄Cl₃CuN₅O

C₂₀H₂₀Cl₂N₄OPd

C₁₈H₁₆Cl₃N₃OPd

C₁₈H₁₆Cl₃N₃OPt

Refernces

• 1、 Arshad, Nasima,Ahmad, Mukhtar,Ashraf, Muhammad Zaman,Nadeem, Humaira. "Spectroscopic, electrochemical DNA binding and in vivo anti-inflammatory studies on newly synthesized Schiff bases of 4-aminophenazone". . p. 331 - 346. Retrieved 2014.
• 2、 Kumari, Mitlesh,Gupta, Ragini,Jain, Yachana. "Preparation of a simple biocompatible magnetite@citric acid: An efficient reusable solid acid catalyst for the rapid synthesis of antipyrine Schiff’s bases and study of their radical scavenging potential". supporting information. p. 529 - 538. Retrieved 2019/02/01.