N-(4-Bromophenyl)-4-(4-fluorophenyl)-2-thiazolamine

Base Information

• Chemical Name: N-(4-Bromophenyl)-4-(4-fluorophenyl)-2-thiazolamine
• CAS No.: 61383-57-1
• Molecular Formula: C15H10BrFN2S
• Molecular Weight: 349.22
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID10366881
• Wikidata: Q82152339
• Mol file: 61383-57-1.mol

Synonyms:61383-57-1;N-(4-Bromophenyl)-4-(4-fluorophenyl)-2-thiazolamine;N-(4-bromophenyl)-4-(4-fluorophenyl)-1,3-thiazol-2-amine;SCHEMBL12297865;DTXSID10366881;STK121203;AKOS002663254;EU-0044532

Chemical Property of N-(4-Bromophenyl)-4-(4-fluorophenyl)-2-thiazolamine

Chemical Property:

• Vapor Pressure: 9.39E-09mmHg at 25°C
• Refractive Index: 1.677
• Boiling Point: 463°C at 760 mmHg
• Flash Point: 233.8°C
• PSA: 53.16000
• Density: 1.56g/cm³
• LogP: 5.52830
• XLogP3: 5.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 347.97321
• Heavy Atom Count: 20
• Complexity: 304

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)Br)F

Technology Process of N-(4-Bromophenyl)-4-(4-fluorophenyl)-2-thiazolamine

There total 2 articles about N-(4-Bromophenyl)-4-(4-fluorophenyl)-2-thiazolamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.4%

1-(4-bromophenyl)thiourea (2646-30-2) + 2-bromo-4'-fluoroacetophenone (403-29-2) → 2-(4-bromophenylamino)-4-(4-fluorophenyl)thiazole (61383-57-1)

Guidance literature:

1-(4-bromophenyl)thiourea; 2-bromo-4'-fluoroacetophenone; In ethanol; at 30 - 35 ℃; for 2.25h; Sonication;

With ammonium hydroxide; In ethanol;

DOI:10.1080/10426500903036014

Reference yield:

→ 2-(4-bromophenylamino)-4-(4-fluorophenyl)thiazole (61383-57-1)

Guidance literature:

entsprechend. Fluorketon, Arylthioharnstoff, Iod (100grad);

upstream raw materials:

1-(4-bromophenyl)thiourea

2-bromo-4'-fluoroacetophenone