Benzenemethanamine, alpha-ethenyl-4-fluoro-, (alphaR)- (9CI)

Base Information

• Chemical Name: Benzenemethanamine, alpha-ethenyl-4-fluoro-, (alphaR)- (9CI)
• CAS No.: 688362-77-8
• Molecular Formula: C₉H₁₀FN
• Molecular Weight: 151.184
• Mol file: 688362-77-8.mol

Synonyms:Benzenemethanamine, alpha-ethenyl-4-fluoro-, (alphaR)- (9CI)

Chemical Property of Benzenemethanamine, alpha-ethenyl-4-fluoro-, (alphaR)- (9CI)

Chemical Property:

• PSA: 26.02000
• LogP: 2.71180

Purity/Quality:

99%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanamine, alpha-ethenyl-4-fluoro-, (alphaR)- (9CI)

There total 4 articles about Benzenemethanamine, alpha-ethenyl-4-fluoro-, (alphaR)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-fluorophenyl)allyl alcohol (5724-03-8) → (R)-1-(4-fluorophenyl)-2-propenylamine (688362-77-8,688362-62-1) + (S)-1-(4-fluorophenyl)-2-propenylamine (688362-62-1)

Guidance literature:

With (S)-(+)-N-(3,5-dioxa-4-phosphacyclohepta-[2,1-a;3,4-a′]dinaphthalen-4-yl)dibenz[b,f]azepine; bis(1,5-cyclooctadiene)diiridium(I) dichloride; aminosulfonic acid; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ja4026787

Reference yield:

4-fluorobenzaldehyde (459-57-4) → (R)-1-(4-fluorophenyl)-2-propenylamine (688362-77-8,688362-62-1)

Guidance literature:

4-fluorobenzaldehyde;

CH₂=CHMgX; In tetrahydrofuran;

With hydrogenchloride; In methanol; Further stages.;

DOI:10.1016/j.bmcl.2007.04.072

Reference yield:

ethyl acetate (141-78-6) + (+/-)-1-(4-fluorophenyl)-2-propenylamine (688362-55-2,688362-62-1) → (R)-1-(4-fluorophenyl)-2-propenylamine (688362-77-8,688362-62-1) + (S)-1-(4-fluorophenyl)-2-propenylamine (688362-62-1) + (S)-N-1-acetyl-1-(4-fluorophenyl)-2-propenylamine + (R)-N-1-acetyl-1-(4-fluorophenyl)-2-propenylamine

Guidance literature:

With Candida antarctica lipase; In diethyl ether; at 20 ℃; for 110h; Title compound not separated from byproducts;

DOI:10.1016/j.tetasy.2004.01.035

upstream raw materials:

ethyl acetate

(+/-)-1-(4-fluorophenyl)-2-propenylamine

4-fluorobenzaldehyde

1-(4-fluorophenyl)allyl alcohol

Downstream raw materials:

C₁₄H₁₈FNO₂

C₂₉H₄₁FN₂O₅

C₃₀H₄₁FN₂O₆