Benzeneacetamide, 4-(acetylamino)-N-[6-amino-1-butyl-3-[(3-fluorophenyl)methyl]-1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinyl]-

Base Information

Chemical Name:Benzeneacetamide, 4-(acetylamino)-N-[6-amino-1-butyl-3-[(3-fluorophenyl)methyl]-1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinyl]-
CAS No.:628279-20-9
Molecular Formula:C₂₅H₂₈FN₅O₄
Molecular Weight:481.527
Hs Code.:
Mol file:628279-20-9.mol

Synonyms:Benzeneacetamide, 4-(acetylamino)-N-[6-amino-1-butyl-3-[(3-fluorophenyl)methyl]-1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinyl]-

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzeneacetamide, 4-(acetylamino)-N-[6-amino-1-butyl-3-[(3-fluorophenyl)methyl]-1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinyl]-

Chemical Property:

PSA：135.20000
LogP:4.59950

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzeneacetamide, 4-(acetylamino)-N-[6-amino-1-butyl-3-[(3-fluorophenyl)methyl]-1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinyl]-

There total 3 articles about Benzeneacetamide, 4-(acetylamino)-N-[6-amino-1-butyl-3-[(3-fluorophenyl)methyl]-1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18699-02-0
4-acetamidophenylacetic acid

: 628279-25-4
5,6-diamino-1-butyl-3-(3-fluoro-benzyl)-1H-pyrimidine-2,4-dione

: 628279-20-9
2-(4-acetylamino-phenyl)-N-[6-amino-1-butyl-3-(3-fluoro-benzyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetamide

Guidance literature:: 5,6-diamino-1-butyl-3-(3-fluoro-benzyl)-1H-pyrimidine-2,4-dione; With 1H-imidazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;

4-acetamidophenylacetic acid; With dmap; In N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00722-4

Reference yield:

: 53681-49-5
6-amino-1-n-butyl-1,3-dihydropyrimidine-2,4-dione

: 628279-20-9
2-(4-acetylamino-phenyl)-N-[6-amino-1-butyl-3-(3-fluoro-benzyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: HMDS; (NH₄)2SO₄ / Heating

1.2: Heating

2.1: aq. NaNO₂; HOAc

2.2: Na₂S₂O₄; NH₄OH / 85 - 95 °C

3.1: EDCI; imidazole

3.2: DMAP / dimethylformamide

With 1H-imidazole; ammonium sulfate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane; sodium nitrite;
DOI:10.1016/S0960-894X(03)00722-4

Reference yield:

: 628279-12-9
6-amino-1-butyl-3-(3-fluoro-benzyl)-1H-pyrimidine-2,4-dione

: 628279-20-9
2-(4-acetylamino-phenyl)-N-[6-amino-1-butyl-3-(3-fluoro-benzyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: aq. NaNO₂; HOAc

1.2: Na₂S₂O₄; NH₄OH / 85 - 95 °C

2.1: EDCI; imidazole

2.2: DMAP / dimethylformamide

With 1H-imidazole; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium nitrite;
DOI:10.1016/S0960-894X(03)00722-4