2(1H)-Pyridinone,5-methoxy-(9CI)

Base Information

• Chemical Name: 2(1H)-Pyridinone,5-methoxy-(9CI)
• CAS No.: 61941-79-5
• Molecular Formula: C6H7NO2
• Molecular Weight: 125.13
• Hs Code.: 2933399090
• Mol file: 61941-79-5.mol

Synonyms:2(1H)-Pyridinone,5-methoxy-(9CI);2-Hydroxy-5-methoxypyridine

Chemical Property of 2(1H)-Pyridinone,5-methoxy-(9CI)

Chemical Property:

• Melting Point: 102-103 °C
• Boiling Point: 355.1±42.0 °C(Predicted)
• PKA: 11.65±0.10(Predicted)
• PSA: 42.35000
• Density: 1.16±0.1 g/cm3(Predicted)
• LogP: 0.79580

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-Hydroxy-5-methoxypyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2(1H)-Pyridinone,5-methoxy-(9CI)

There total 4 articles about 2(1H)-Pyridinone,5-methoxy-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-amino-5-methoxypyridine (10167-97-2) → 2-hydroxy-5-methoxypyridine (61941-79-5,95907-07-6)

Guidance literature:

2-amino-5-methoxypyridine; With sodium nitrite; In sulfuric acid; water; at 0 - 5 ℃; for 0.5h;

With copper(II) sulfate; In water; Heating;

DOI:10.3987/com-01-9363

Reference yield: 64.0%

2-bromo-5-methoxypyridine (105170-27-2) → 2-hydroxy-5-methoxypyridine (61941-79-5,95907-07-6)

Guidance literature:

With syn-benzaldehyde oxime; N¹,N²-bis(thiophen-2-ylmethyl)oxalamide; caesium carbonate; copper(l) chloride; In dimethyl sulfoxide; at 80 ℃; for 20h; Reagent/catalyst; Temperature; Glovebox; Schlenk technique; Sealed tube; Inert atmosphere;

DOI:10.1002/cctc.201900393

Reference yield:

5-bromo-2-pyridylamine (1072-97-5) → 2-hydroxy-5-methoxypyridine (61941-79-5,95907-07-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 44 percent / Cu powder / methanol / 12 h / 100 °C

2.1: NaNO₂ / H₂SO₄; H₂O / 0.5 h / 0 - 5 °C

2.2: 72 percent / CuSO₄*5H₂O / H₂O / Heating

With copper; sodium nitrite; In methanol; sulfuric acid; water;

DOI:10.3987/com-01-9363

upstream raw materials:

2-amino-5-methoxypyridine

5-bromo-2-pyridylamine

2-bromo-5-methoxypyridine

Downstream raw materials:

2-(5-methoxy-2-phenylfuro[2,3-b]pyridin-3-yl)acetonitrile

3-bromo-2-methoxyfuro[2,3-b]pyridine

5-methoxy-3-methyl-2-phenylfuro[2,3-b]pyridine

5-methoxy-2-phenylfuro[2,3-b]pyridine

Refernces

• 1、 Van De Po?l, Hervé,Guillaumet, Gérald,Viaud-Massuard, Marie-Claude. "Synthesis of melatonin analogues derived from furo[2,3-b]- and [2,3-c]pyridines by use of a palladium-copper catalyst system". . p. 55 - 71. Retrieved 2007/10/03.