5-Bromo-N-cyclopropylpyridine-2-carboxamide

Base Information

• Chemical Name: 5-Bromo-N-cyclopropylpyridine-2-carboxamide
• CAS No.: 638219-77-9
• Molecular Formula: C9H9BrN2O
• Molecular Weight: 241.08
• Hs Code.: 2933399090
• Mol file: 638219-77-9.mol

Synonyms:5-Bromo-N-cyclopropylpicolinamide;5-Bromo-N-cyclopropylpyridine-2-carboxamide;N-Cyclopropyl 5-bromopicolinamide;N-cyclopropyl 5-bromopyridine-2-carboxamide

Chemical Property of 5-Bromo-N-cyclopropylpyridine-2-carboxamide

Chemical Property:

• Vapor Pressure: 2.83E-06mmHg at 25°C
• Refractive Index: 1.625
• Boiling Point: 389.5ºC at 760 mmHg
• PKA: 13.24±0.20(Predicted)
• Flash Point: 189.4ºC
• PSA: 41.99000
• Density: 1.62g/cm3
• LogP: 2.12720
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

N-Cyclopropyl 5-bromopicolinamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-N-cyclopropylpyridine-2-carboxamide

There total 3 articles about 5-Bromo-N-cyclopropylpyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

5-bromoisonicotinic acid (30766-11-1) + Cyclopropylamine (765-30-0) → 5-bromo-2-(N-cyclopropylaminocarbonyl)pyridine (638219-77-9)

Guidance literature:

5-bromoisonicotinic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 0.5h;

Cyclopropylamine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 5h;

DOI:10.1021/acs.jmedchem.1c01792

Reference yield:

5-bromopyridine-2-carbonyl chloride (137178-88-2) + Cyclopropylamine (765-30-0) → 5-bromo-2-(N-cyclopropylaminocarbonyl)pyridine (638219-77-9)

Guidance literature:

In dichloromethane; at 18 - 25 ℃; for 2h;

Reference yield:

→ 5-bromo-2-(N-cyclopropylaminocarbonyl)pyridine (638219-77-9)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Cooling with ice;

upstream raw materials:

5-bromopyridine-2-carbonyl chloride

Cyclopropylamine

5-bromoisonicotinic acid

Downstream raw materials:

5-bromo-1-oxy-pyridine-2-carboxylic acid cyclopropylamide